Comparison of two medicines i.e. phenylephrine and norepinephrine for increasing blood pressure during caesarean delivery under spinal anaesthesia in patients with preeclampsia

Phase 4

Completed

• Conditions: Health Condition 1: O149- Unspecified pre-eclampsia

• Registration Number: CTRI/2018/11/016478
• Lead Sponsor: niversity College of Medical Sciences and Guru Teg Bahadur Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2020-03-20
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 86

Inclusion Criteria

1. Preeclamptic females with singleton pregnancy undergoing caesarean section under spinal anaesthesia

2. Preeclampsia diagnosed as BP > 140/90 mmHg on two or more occasions at least 4 hrs apart and proteinuria > 300 mg/ 24 hrs or > 1+ dipstick test

Exclusion Criteria

1. Maternal complications other than preeclampsia e.g. chronic hypertension, other cardiovascular disease, cerebrovascular disease

2. Multiple gestation

3. Known fetal abnormality

4. Patients with absolute or relative contra-indications for spinal anaesthesia e.g. infection in lumbar area, coagulation abnormalities, platelet count < 75 x 109/l, autonomic neuropathy, spinal deformities, other neurological diseases.

5. Severe fetal distress or other conditions requiring immediate induction of general anaesthesia

6. Patients on monoamine oxidase inhibitors or tricyclic antidepressants

7. History suggestive of mesenteric or peripheral vascular thrombosis

Study & Design

• Study Type: Interventional
• Study Design: Not specified