Comparison of two medications used to increase blood pressure i.e. phenylephrine and norepinephrine for treatment of fall in bloodpressure during caesarean delivery under spinal anaesthesia in patients with babies in compromised situatio
- Conditions
- Health Condition 1: O469- Antepartum hemorrhage, unspecifiedHealth Condition 2: O68- Labor and delivery complicated byabnormality of fetal acid-base balanceHealth Condition 3: O410- Oligohydramnios
- Registration Number
- CTRI/2018/12/016518
- Lead Sponsor
- niversity College of Medical Sciences and Guru Teg Bahadur Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 100
1. Healthy females with singleton pregnancy undergoing emergency caesarean section for potential fetal compromise under spinal anaesthesia
2. Non-reassuring fetal heart rate (FHR) status i.e. FHR more than 160 or less than 100 bpm
3. FHR deceleration(variable or late), which fails to recover after uterine contraction has passed (type 2 dips)
4. Meconium stained liquor with FHR abnormality or thick meconium stained liquor
5. Cord prolapse
6. Intra-uterine growth restriction
7. Oligohydramnios
8. Antepartum haemorrhage
9. Dystocia
10. Postmaturity
11. Prematurity
1. Maternal complications e.g. pre-eclampsia, cardiovascular disease, cerebrovascular disease
2. Multiple gestation
3. Known fetal abnormality
4. Patients with absolute or relative contra-indications for spinal anaesthesia e.g. infection in lumbar area, coagulation abnormalities, autonomic neuropathy, spinal deformities, other neurological diseases, hypovolemia due to any cause
5. Maternal baseline SBP less than 100 mmHg
6. Severely compromised fetus requiring immediate administration of general anaesthesia to mother
7. Patients on monoamine oxidase inhibitors or tricyclic antidepressants
8. History suggestive of mesenteric or peripheral vascular thrombosis
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method â?¢ Umbilical artery pHTimepoint: â?¢Time of delivery of baby
- Secondary Outcome Measures
Name Time Method â?¢ APGAR scores at 1 and 5 minutes <br/ ><br>â?¢ Incidence of fetal acidosis, defined as umbilical artery pH less than 7.20 <br/ ><br>â?¢ Number of neonates requiring admission to neonatal intensive care unit with their duration of stay <br/ ><br>â?¢ Total dose of vasopressor given <br/ ><br>â?¢ Number of episodes of hypotension <br/ ><br>â?¢ Incidence of bradycardia/ tachycardia/ arrhythmias <br/ ><br>â?¢ Incidence of nausea, vomiting, dizziness or any other complications <br/ ><br>Timepoint: Till the time of delivery of baby