Comparison of phenylephrine and norepinephrine boluses for treatment of fall in blood pressure during planned caesarean section under spinal anaesthesia
- Conditions
- Health Condition 1: null- Spinal Anaesthesia induced Hypotension in Elective caesarean section
- Registration Number
- CTRI/2016/12/007541
- Lead Sponsor
- niversity College of Medical Sciences and Guru Teg Bahadur Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 90
Healthy females with term, uncomplicated, singleton pregnancy undergoing elective caesarean section under spinal anaesthesia
•Maternal complications e.g. diabetes, pre-eclampsia, cardiovascular disease, cerebrovascular disease, renal impairment
•Placental complications viz., placenta praevia or abruptio placentae
•Cord complications viz., nuchal cord or cord prolapse
•Fetal malformations
•Multiple gestation
•Patients with absolute or relative contra-indications for spinal anaesthesia e.g. infection in lumbar area, coagulation abnormalities, autonomic neuropathy, spinal deformities, other neurological diseases, hypovolemia due to any cause
•Patients on monoamine oxidase inhibitors or tricyclic antidepressants
•Presence of mesenteric or peripheral vascular thrombosis
•Maternal baseline SBP less than 100 mmHg
•Patients with baby birth weight less than 2.5 kg or greater than 4.5 kg
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method incidence of maternal bradycardia (HR less than 60)Timepoint: till delivery of baby
- Secondary Outcome Measures
Name Time Method <br/ ><br>â?¢Changes in maternal SBP after vasopressor administration <br/ ><br>â?¢Number of episodes of hypotension <br/ ><br>â?¢Total number of vasopressor doses given <br/ ><br>â?¢Incidence of reactive hypertension and arrhythmias <br/ ><br>â?¢Incidence of nausea, vomiting, dizziness or any other complications <br/ ><br>â?¢Apgar scores at 1 and 5 minutes <br/ ><br>â?¢Umbilical artery pH <br/ ><br>â?¢Incidence of fetal acidosis, defined as umbilical artery pH less than 7.20Timepoint: till delivery of baby