SOCIAL-EMOTIONAL BEHAVIOUR IN MALE PSYCHOPATHS AFTER DOUBLE-BLIND PLACEBO-CONTROLLED ADMINISTRATION OF INTRANASAL OXYTOCI

Recruiting

Conditions: Persoonlijkheidsstoornis (psychopathie)
psychopathy
empathy

Registration Number: NL-OMON39859

Lead Sponsor: niversiteit Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 20

Inclusion Criteria

- MALE SEX;;- DIAGNOSIS OF PSYCHOPATHY ACCORDING TO PSYCHOPATHY CHECKLIST - REVISED;;- GOOD PHYSICAL HEALTH;;- AGE BETWEEN 18 AND 60;;- NORMAL OR CORRECTED TO NORMAL VISION; ;- INTELLIGENCE NO LESS THAN BORDERLINE INTELLCTUAL FUNCTIONING.

Exclusion Criteria

- OVERSENSITIVITY FOR OXYTOCIN OR CARRIER;;- COLOUR BLINDNESS;;- ILLITERATE OR INSUFFICIENT KNOWLEDGE OF DUTCH LANGUAGE;;- USE OF SSRI'S, MOOD STABILIZERS (E.G. LITHIUM), ANTIPSYCHOTICS OR HORMONAL TREATMENT FOR LIBIDO INHIBITION;;- USE OF ALCOHOL OR RECREATIONAL DRUGS WITHIN LAST 24 HOURS;;- CURRENT PSYCHOTIC DISORDER;;- CURRENT SEVERE DEPRESSIVE DISORDER;;- CURRENT SEVERE ANXIETY DISORDER;;- COMMON COLD WITH SEVERE RUNNING NOSE, CURENTLY OR WITHIN PREVIUOS SEVEN DAYS;;- HISTORY OF NEUROLOGICAL TREATMENT OF BRAIN STRUCTURES OR CURRENT NEUROLOGICAL TREATMENT;;- HISTORY OF ENDOCRINOLOGICAL TREATMENT OR CURRENT ENDOCRINOLOGICAL TREATMENT;;- HISTORY OF SEVERE CLOSED HEAD INJURY WITH LOSS OF CONSCIOUSNESS >15 MINUTES;;- PATIENT'S LEGAL INCAPACITY.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Reading the Mind in the Eyes Test (Baron Cohen, 2001);<br /><br>- Subjective feelings of affective empathy on a Visual Analogue Scale, conform<br /><br>the Multifaceted Empathy Test (MET; Dziobek et al., 2008);<br /><br>- Facial electromyographic (EMG) mimicry recording of the zygomaticus major and<br /><br>the corrugator supercilii muscle activity, following basic emotion inducing<br /><br>film fragments, </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The equilibrium of the parasympathetic and sympathetic nerve system will be<br /><br>measured in terms of heart rate, respiration and skin conductance;<br /><br>Saliva sampling before and after test procedures, reflecting baseline<br /><br>functioning of the HPA-axis (cortisol) and HPG-axis (testosterone and<br /><br>estradiol). </p><br>