Investigating The Most Effective Exercise Modality in Knee Osteoarthritis; A RCT
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Knee OA
- Sponsor
- Uludag University
- Enrollment
- 69
- Locations
- 1
- Primary Endpoint
- Quadriceps Isometric Muscle Strength
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The goal of this clinical trial is to assess and compare the effectiveness of three different exercise modalities-whole-body vibration exercise, progressive resistance exercise, and home-based exercise -in improving quadriceps isometric muscle strength, physical function, balance, knee pain, osteoarthritis symptoms, and overall quality of life in individuals with knee osteoarthritis.
The main questions it aims to answer are:
- How do WBV, PRE, and home-based exercise compare in improving quadriceps strength in people with knee osteoarthritis?
- Which exercise modality leads to the greatest improvements in physical function, balance, knee pain, and quality of life?
Researchers will compare the three exercise regimens to determine which is most effective for improving knee function and relieving osteoarthritis symptoms.
Participants will:
- Engage in whole-body vibration exercise, progressive resistance exercise, or home-based exercise for 3 weeks.
- Undergo assessments before and at the end of the exercise program, including tests for physical function and balance (Timed Up and Go Test, 5x Sit to Stand Test) and questionnaires to evaluate knee osteoarthritis symptoms (WOMAC), quality of life (SF-36), and self-reported knee pain (Numeric Rating Scale).
Investigators
Mustafa Alabdallah Alalewy
Principal Investigator
Uludag University
Eligibility Criteria
Inclusion Criteria
- •participants between the ages of 45-70,
- •diagnosed with knee osteoarthritis according to ACR criteria (unilateral or bilateral),
- •having grade 2 or 3 tibiofemoral knee osteoarthritis according to Kellgren-Lawrence staging,
- •having knee pain due to OA for a minimum of 3 months prior to enrollment,
- •patients whose medical treatment is not expected to change during the study period.
Exclusion Criteria
- •having or had undergone knee surgery,
- •patients unable to walk without support,
- •having musculoskeletal limitations that prevent participation in resistance exercises (contracture, fracture, etc.),
- •other neurological, cardiac, respiratory and systemic diseases that will affect physical activity,
- •currently implementing a regular exercise or physical therapy program specific to knee OA
Outcomes
Primary Outcomes
Quadriceps Isometric Muscle Strength
Time Frame: at baseline and 3-weeks
Quadriceps isometric muscle strength is measured using an Isokinetic dynamometer (CSMI Humac Norm, Stoughton, MA). Measurements are taken in a sitting position with the knee positioned at two angles: 30° and 60° of flexion. For each angle, one trial is performed followed by three real measurements, with the highest peak torque recorded in Newton-meters (Nm). Participants are secured to the dynamometer, and all settings and positions are standardized. Prior to measurements, the device is calibrated, and participants perform a 5-minute warm-up and familiarize themselves with the test procedure. Verbal encouragement is provided during the tests.
Secondary Outcomes
- Timed Up and Go (TUG) Test (Physical Function and Balance)(at baseline and 3-weeks)
- Five Times Sit to Stand Test (5xSST) (Physical Function and Balance)(at baseline and 3-weeks)
- Numeric Rating Scale (NRS) (Self-reported Knee Pain)(at baseline and 3-weeks)
- WOMAC (Knee Osteoarthritis Symptoms and Function)(at baseline and 3-weeks)
- SF-36 (Quality of Life)(at baseline and 3-weeks)