Effect of sugar ingestion on forearm blood flow in male offspring of hypertensive parents

Phase 1

Recruiting

• Conditions: ormotensive offspring of hypertensive parents; Sugar; Postprandial hyperglycemia; Forearm blood flow; Hypertension; Oxidative stress

• Registration Number: TCTR20201127002
• Lead Sponsor: Research affairs, Faculty of Medicine, Chulalongkorn University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-11-27
• Study Completion: 2021-02-26
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Male
• Target Recruitment: 32

Inclusion Criteria

1.Men whose age between 18-35 years
2.Healthy: normal blood pressure, normal fasting blood sugar, normal blood lipid levels and normal resting cardiac electrical signals
3.Sedentary lifestyle: physical activity of moderate intensity < 30 min/times, < 3 times/week for at least 3 months
4.BMI < 25 kg/m2
5.Farther and/or mother having high blood pressure records
(the diagnosis made before 55 for father and 65 for mother) or currently on antihypertensive medicine for OHT group
6.Farther and/or mother having normal blood pressure records for ONT group
7.Without family history of diabetic

Exclusion Criteria

1.Abnormalities in nerve and upper limb muscles
2.An open wound or muscle inflammation in arm and forearm area
3.Use medications for cardiovascular disease (include beta-blockers)
4.Use medications for decreased blood sugar

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Peak forearm blood flow (FBF) before and every 30 minutes after sugar ingestion for a period of 2 hours. venous occlusion plethysmography

Secondary Outcome Measures

Name	Time	Method
Plasma glucose level before and at 30, 60, and 120 minutes after sugar ingestion. Plasma glucose level was measured by Hexokinase/ G-6-PDH,Serum insulin level before and at 30, 60, and 120 minutes after sugar ingestion. Serum insulin level was measured by Chemiluminescence immunoassay (CLIA),Oxidative stress makers before and at 30, 60, and 120 minutes after sugar ingestion. DNPH assay, ABTS and DPPH assay