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临床试验/NCT01580150
NCT01580150已完成不适用

Effects of Berries on Postprandial Glycemic Responses to Sucrose and Starch

Marjukka Kolehmainen2 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2009年11月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
20
试验地点
2
主要终点
Plasma glucose

研究概览

简要总结

The purpose of this study is to investigate whether berries are effective in lowering blood glucose and insulin responses to meals containing starch or sucrose.

详细描述

Berries are rich sources of various polyphenols which may be beneficial in the regulation of blood glucose. In vitro and animal studies have shown that polyphenols and polyphenol-rich extracts of foods, including berries, may inhibit digestion and absorption of carbohydrates and thereby suppress postprandial glycemia. However, current evidence on the effects of berries on postprandial glycemic responses in humans is limited.

The purpose of this study is to investigate the effects of berries on postprandial glycemic responses (blood glucose and insulin) to starch or sucrose in healthy subjects. It consists of five substudies each of which includes 2-4 meals with different berry species typically consumed in Finland and a reference meal without berries. The following combinations of carbohydrates and berries are studied:

  • Studies 1-2: white wheat bread (starch) is consumed with several berry species
  • Study 3: white wheat bread or rye bread is consumed with a mixture of berries
  • Study 4: sugar (sucrose) is consumed with berries and berry nectars
  • Study 5: a sugar-sweetened bakery product (starch + sucrose) is consumed with berries and berry nectar.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
None

入排标准

年龄范围
25 Years 至 69 Years(Adult, Older Adult)
接受健康志愿者

入选标准

  • BMI 20-28 kg/m2
  • normal fasting plasma glucose

排除标准

  • Diabetes or other chronic disease
  • Antibiotic medication within the past 3 months
  • Blood donation within the past month

结局指标

主要结局

Plasma glucose

时间窗: 0, 15, 30, 45, 60, 90, 120 minutes post-meal

Plasma insulin

时间窗: 0, 15, 30, 45, 60, 90, 120 minutes post-meal

次要结局

  • Plasma free fatty acids(0, 15, 30, 45, 60, 90, 120 minutes post-meal)

研究者

发起方
Marjukka Kolehmainen
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Marjukka Kolehmainen

Senior scientist

University of Eastern Finland

研究点 (2)

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