Effects of Berries on Postprandial Glycemic Responses to Sucrose and Starch
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Plasma glucose
研究概览
简要总结
The purpose of this study is to investigate whether berries are effective in lowering blood glucose and insulin responses to meals containing starch or sucrose.
详细描述
Berries are rich sources of various polyphenols which may be beneficial in the regulation of blood glucose. In vitro and animal studies have shown that polyphenols and polyphenol-rich extracts of foods, including berries, may inhibit digestion and absorption of carbohydrates and thereby suppress postprandial glycemia. However, current evidence on the effects of berries on postprandial glycemic responses in humans is limited.
The purpose of this study is to investigate the effects of berries on postprandial glycemic responses (blood glucose and insulin) to starch or sucrose in healthy subjects. It consists of five substudies each of which includes 2-4 meals with different berry species typically consumed in Finland and a reference meal without berries. The following combinations of carbohydrates and berries are studied:
- Studies 1-2: white wheat bread (starch) is consumed with several berry species
- Study 3: white wheat bread or rye bread is consumed with a mixture of berries
- Study 4: sugar (sucrose) is consumed with berries and berry nectars
- Study 5: a sugar-sweetened bakery product (starch + sucrose) is consumed with berries and berry nectar.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 69 Years(Adult, Older Adult)
- 接受健康志愿者
- 是
入选标准
- •BMI 20-28 kg/m2
- •normal fasting plasma glucose
排除标准
- •Diabetes or other chronic disease
- •Antibiotic medication within the past 3 months
- •Blood donation within the past month
结局指标
主要结局
Plasma glucose
时间窗: 0, 15, 30, 45, 60, 90, 120 minutes post-meal
Plasma insulin
时间窗: 0, 15, 30, 45, 60, 90, 120 minutes post-meal
次要结局
- Plasma free fatty acids(0, 15, 30, 45, 60, 90, 120 minutes post-meal)
研究者
Marjukka Kolehmainen
Senior scientist
University of Eastern Finland
