Investigation on Effect of Brazilian Fruits on Glucose and Insulin Responses, Anti-inflammatory Properties, Antioxidative Capacity and Satiety in Healthy Subjects
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 17
- 试验地点
- 2
- 主要终点
- Changing on blood glucose concentration after treatment with brazilian fruits peel
研究概览
简要总结
The purpose of the study was to investigate how Brazilian fruits peel affect acute/postprandial glucose and insulin responses, inflammatory markers, appetite control peptides, antioxidative capacity, as well as subjective appetite ratings (VAS-visual analogue scales) in healthy volunteers. We hypothesize that certain Brazilian fruits peel added to a standardized meal will improve postprandial glucose tolerance and other metabolic biomarkers in healthy volunteers, compared with a similar meal without the corresponding plant materials.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy males and females
- •Signed informed consent
- •BMI 20 - 28 kg/m2 with weight change <3 kg latest 2 months
- •Must be able to accept plant-based foods/drinks
排除标准
- •Below 18 years
- •Uncomfortable speaking English and/or difficulties in understanding spoken English
- •Smoking or using snuff
- •Vegetarian or vegan
- •Stressed by venous blood sampling or previous experience of being difficult to cannulate
- •Receiving any drug treatment that may influence the study outcomes
- •Pregnancy or breastfeeding
结局指标
主要结局
Changing on blood glucose concentration after treatment with brazilian fruits peel
时间窗: Prior to the initial intervention at 0 min and after intervention at 15, 30, 45, 60, 90, 120, 180 min
The capillary blood samples will be taken for blood glucose analysis
次要结局
- Identify plasma metabolite profile (untargeted approach) after treatment with Brazilian fruits peel(Prior to the initial intervention at 0 min and after intervention at 60, 90, 120, 180 min.)
- Changing on appetite markers (i.e. ghrelin, cholecystokinin, glucagon-like peptide-1, gastric inhibitory polypeptide, peptide YY, amylin, pancreatic polypeptide) after treatment with Brazilian fruits peel(Prior to the initial intervention at 0 min and after intervention at 15, 30, 45, 60, 90, 120, 180 min.)
- Changing on subjective appetite ratings after treatment with Brazilian fruits peel(Prior to the initial intervention at 0 min and after intervention at 15, 30, 45, 60, 90, 120, 180 min.)
- Changing on insulin after treatment with Brazilian fruits peel(Prior to the initial intervention at 0 min and after intervention at 15, 30, 45, 60, 90, 120, 180 min.)
- Changing on inflammatory markers (i.e. interleukin-6, interleukin-8, tumor necrosis factor-alpha, necrosis factor kappa-beta, adiponectin and C-reactive protein) after treatment with Brazilian fruits peel(Prior to the initial intervention at 0 min and after intervention at 15, 30, 45, 60, 90, 120, 180 min.)
研究者
Elin Östman
Assoc. Prof, PhD
Lund University