Effects of Berry Peel Intake on Glucose Metabolism in Healthy Subjects
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 2
- 主要终点
- Postprandial blood glucose response after acute intervention
研究概览
简要总结
The main objective of this study is to investigate the effect of a 4-weeks intake of berry peel powder on fasting and postprandial glucose metabolism and inflammatory markers. The berry peel product will be compared with a placebo in a single-blind, cross-over design. Furthermore, inflammation-related peripheral blood mononuclear cells (PBMCs) genes expression, appetite and cognitive performance will be included as a pilot study. Investigators hypothesize that long-term consumption of polyphenols and fibres of berry peel will exhibit both direct and indirect actions in healthy overweight subjects by improvement of glucose-associated markers as well as ameliorating inflammation. Moreover, above metabolic markers will correlated with improvements in inflammation-related PBMCs genes expression, subjective appetite and cognitive performance after long-term consumption of berry peel as a source of polyphenols.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy males and females
- •Signed informed consent
- •BMI 25-30 kg/m2
- •Must be able to accept plant-based foods/drinks
排除标准
- •Below 18 years or above 40 years
- •Smoking or using snuff
- •vegetarian or vegan
- •Stressed by venous blood sampling or previous experience of being difficult canulation
结局指标
主要结局
Postprandial blood glucose response after acute intervention
时间窗: -30, 0, 15, 30, 45, 60, 120, and 180 min after challenge meal.
The capillary blood will be collected for glucose analysis using a glucometer.
Incremental area under curve (iAUC) blood glucose response after long-term intervention
时间窗: 4 weeks
The capillary blood will be collected for glucose analysis using a glucometer.
次要结局
- Postprandial subjective appetite rating after acute intervention(-30, 0, 15, 30, 45, 60, 120, and 180 min.)
- Incremental area under curve (iAUC) of interleukin-6 (IL-6) after long-term intervention(4 weeks)
- Incremental area under curve (iAUC) of C-reactive protein (CRP) after long-term intervention(4 weeks)
- Peripheral blood mononuclear cells (PBMCs) inflammatory genes expression after acute intervention(180 min after challenge meal.)
- Postprandial interleukin-6 (IL-6) after acute intervention(-30, 60, 120, and 180 min.)
- Postprandial adiponectin after acute intervention(-30, 0, 60, 120, and 180 min.)
- Postprandial selective attention after long-term intervention(45, 90, and 180 min after challenge meal.)
- Postprandial serum insulin response after acute intervention(-30, 0, 15, 30, 45, 60, 120, and 180 min.)
- Incremental area under curve (iAUC) serum insulin response after long-term intervention(4 weeks)
- Incremental area under curve (iAUC) subjective appetite rating after long-term intervention(4 weeks)
- Postprandial C-reactive protein (CRP) after acute intervention(-30, 60, 120, and 180 min.)
- Postprandial adiponectin after long-term intervention with berry peel(4 weeks)
- Peripheral blood mononuclear cells (PBMCs) inflammatory genes expression after long-term intervention(-30 min. (Day-28 control); 180 min. (Day-28 control); -30 min. (Day-28 berry); 180 min. (Day-28 berry))
研究者
Elin Östman
Assoc. Prof., PhD
Lund University