The association between loss of gut wall integrity as measured by ZOnulin and hepatic ischaemia as measured by NIRS and Biliary Atresia development
Withdrawn
- Conditions
- bile duct atresiabiliary atresia10019654
- Registration Number
- NL-OMON41086
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Suspected biliary atresia, as controls patients with pyloric stenosis (same age group but without liver disease)
Exclusion Criteria
No biliary atresia during surgery, other gastro-intestinal diseases (except pyloric hypertrophy)
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Serum Zonulin levels and liver NIRS</p><br>
- Secondary Outcome Measures
Name Time Method <p>Other serum tight junction and translocation markers (e.g. Claudin 3 and/or LBP)<br /><br><br /><br>Histologic assessment of the tight junction complex in the small bowel, VEGF-A<br /><br>expression in the liver</p><br>