The Effect of Adding Epinephrine To Combination of 0.5% Hyperbaric Bupivacaine and Dexmedetomidine in Intrathecal Anaesthesia- A Prospective, Double Blinded Randomized Control Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- NOT APPLICABLE
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Duration of analgesia
Study Overview
Brief Summary
This study is designed to evaluate intrathecal anesthesia and postoperative analgesia of adding epinephrine to a combination of 0.5% hyperbaric bupivacaine and dexmedetomidine.
Dexmedetomidine, a highly selective α2 adrenergic agonist increases the duration of anesthesia & analgesia whereas Epinephrine, a vasoconstrictor, reduces the systemic toxicity by decreased absorption of local anesthetics into the bloodstream and extends the duration of anesthesia.
We are expecting that the decrease in heart rate and blood pressure with a combination of bupivacaine and dexmedetomidine is balanced by adrenaline as it increases the same resulting in prolonged anesthesia with better hemodynamic status.
Study Design
- Study Type
- Interventional
- Allocation
- Computer generated randomization
- Masking
- Participant, Investigator and Outcome Assessor Blinded
Eligibility Criteria
- Ages
- 15.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •ASA GRADE 1 AND 2 LOWER LIMB SURGERIES WITH PROBABLE DURATION OF 2 HOURS.
Exclusion Criteria
- •Patients refusal Contraindication to regional anesthesia Coagulopathy History of significant coexisting diseases (IHD, impaired renal functions, and severe liver disease) Chronic alcoholics and malnourished patients Atrioventricular block, incomplete or partial heart blocks, or intake of beta blockers.
Outcomes
Primary Outcomes
Duration of analgesia
Time Frame: EVERY 15 MINUTES POST OPERATIVELY
Secondary Outcomes
- Duration of sensory block & motor block(EVERY 15 MINUTES POST OPERATIVELY)