EFFECT OF ADDING EPINEPHRINE TO COMBINATION OF ISOBARIC ROPIVACAINE AND DEXMEDETOMIDINE IN EPIDURAL ANAESTHESIA

Completed

Conditions: Injuries to the ankle and foot, (2) ICD-10 Condition: S70-S79||Injuries to the hip and thigh, (3) ICD-10 Condition: S80-S89||Injuries to the knee and lower leg, (4) ICD-10 Condition: O||Medical and Surgical, (5) ICD-10 Condition: V99||Unspecified transport accident,

Registration Number: CTRI/2021/01/030449

Lead Sponsor: NOT APPLICABLE

Brief Summary: The study is designed to evaluate efficacy of epidural anesthesia and postoperative analgesia by adding epinephrine to a combination of ropivacaine and dexmedetomidine in lower limb surgeries.

Epidural Dexmedetomidine as an adjuvant to Ropivacaine is associated with prolonged sensory and motor blockade, hemodynamic stability, prolonged postoperative analgesia and reduced demand for rescue analgesics when compared to plain Ropivacaine.

Whereas Epinephrine, a vasoconstrictor, decreases the absorption of local anesthetics into the bloodstream, which reduces its systemic toxicity when used as an adjuvant. Resulting, prolonged duration of anesthesia. It is also widely used for early differentiation of intravascular absorption.

In previous studies epinephrine improves the pain relief and reduces the side effects of a thoracic epidural infusion of ropivacaine and fentanyl after major thoracic or upper abdominal surgery.

We hypothesized that epidural isobaric 0.75% ropivacaine with dexmedetomidine and 1:1000 adrenaline would be comparable to isobaric 0.75% ropivacaine with dexmedetomidine and normal saline, for the efficacy of anesthesia and analgesia, and in addition would provide a better postoperative recovery profile and readiness for discharge. The purpose of the present study is to observe the effect of mentioned study drugs in epidural anaesthesia for duration of sensory and motor block with duration analgesia.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 50

Inclusion Criteria

ASA 1 & 2 Lower limb surgery of probable duration of 2hrs.

Exclusion Criteria

patients refusal Contradiction to regional anaesthesia Coagulopathy History of significant coexisting diseases like ischemic heart disease, hypertension, impaired renal functions, rheumatoid arthritis, and severe liver disease Pregnant patients Chronic alcoholics and malnourished patients Atrioventricular block, incomplete or partial heart blocks or intake of beta blockers.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Duration of analgesia	After 2hrs every 15 minutes

Secondary Outcome Measures

Name	Time	Method
Duration of sensory block & motor block	After 2hrs every 15 minutes

Trial Locations

Locations (1): TRAUMA CENTER INSTITUTE OF MEDICAL SCIENCES BHU
🇮🇳
Varanasi, UTTAR PRADESH, India
TRAUMA CENTER INSTITUTE OF MEDICAL SCIENCES BHU
🇮🇳Varanasi, UTTAR PRADESH, India
DR GHANSHYAM YADAV
Principal investigator
9838894169
ghanshyambhu1976@gmail.com