Effect of Adding Epinephrine to Bupivacaine and Dexmedetomidine in Ephinephrine Anaesthesia for Lower Limb Surgeries

Completed

• Registration Number: CTRI/2021/01/030282
• Lead Sponsor: NOT APPLICABLE

Brief Summary

This study is designed to evaluate epidural anaesthesia and postoperative analgesia by adding epinephrine to combination of bupivacaine and dexmedetomidine.



In earlier studies, the use of dexmedetomidine as an adjuvant to bupivacaine is a good alternative to other adjuvants like fentanyl in epidural anesthesia, and dexmedetomidine has an edge over fentanyl as an adjuvant when used with bupivacaine in epidural anesthesia. Whereas, addition of epinephrine to bupivacaine resulted in longer duration of analgesia in comparison to plain bupivacaine in labor analgesia.



We hypothesized that epidural 0.5% bupivacaine with dexmedetomidine and adrenaline 1:1000 would be comparable to 0.5% bupivacaine with dexmedetomidine and normal saline, for the efficacy of anesthesia and analgesia, and in addition would provide a better postoperative recovery profile and readiness for discharge.The purpose of the present study is to observe the effect of mentioned study drugs in epidural anaesthesia for duration of sensory and motor block with duration of analgesia.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-13
• Study Completion: 2023-11-30
• Last Update Posted: 2024-02-13

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

ASA 1 & 2 Lower limb surgery of probable duration of 2hrs.

Exclusion Criteria

Patients refusal Contradiction to regional anaesthesia Coagulopathy History of significant coexisting diseases like ischemic heart disease, hypertension, impaired renal functions, rheumatoid arthritis, and severe liver disease Pregnant patients Chronic alcoholics and malnourished patients Atrioventricular block, incomplete or partial heart blocks or intake of beta-blockers.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Duration of analgesia	After 2 hours every 15 minutes

Secondary Outcome Measures

Name	Time	Method
Duration of sensory block & motor block	After 2 hours every 15 minutes

Trial Locations

Locations (1)

TRAUMA CENTER IMS BHU; 🇮🇳 Varanasi, UTTAR PRADESH, India

TRAUMA CENTER IMS BHU

🇮🇳Varanasi, UTTAR PRADESH, India

DR SHEKHAR ANAND

Principal investigator

9389006418

shekharanand989@gmail.com