Correlation Between Postoperative Cognitive Dysfunction and Telomere Length in Patients With Non-cardiac Surgery

• Conditions: Postoperative Cognitive Dysfunction
• Interventions: Diagnostic Test: Neuropsychology test

• Registration Number: NCT03703973
• Lead Sponsor: Xuzhou Medical University

Brief Summary

To study on the Postoperative Cognitive Dysfunction: Correlations With Leukocyte telomere length。

Detailed Description

Not available

Study Timeline

• Study Start: 2016-08-01
• Study First Submitted: 2018-09-27
• Status Verified: 2018-10
• Study First Submitted QC: 2018-10-10
• Last Update Submitted: 2018-10-10
• Study First Posted: 2018-10-12
• Last Update Posted: 2018-10-12
• Primary Completion: 2020-12-31
• Study Completion: 2020-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• Non-cardiac surgery patients;

  • Age is greater than or equal to 65 years old;

    • Han Nationality, mother tongue is chinese;

      ④The MMSE score:Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points;

      ⑤The Geriatric Depression Scale (GDS) grade 1 or 2;

      ⑥The important function without serious heart, brain, liver, kidney, lung and other organs;

      • The ASA class I or II;

        • The people signed informed consent.

Exclusion Criteria

• The diagnosis of neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's syndrome, multiple sclerosis, schizophrenia, depression, etc.; ②Had severe head and face disease, trauma history or history of surgery;

  • Had a history of influenza in 3 weeks; ④The serious body disease and tobacco, wine and other substance abuse history; ⑤The presence of malignant tumor with shorter survival disease.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
study group	Neuropsychology test	1000 Male and female patients undergoing non-cardiac surgery at the Affiliated Hospital of Xuzhou Medical University \[Jiangsu China\]. We do the neuropsychological tests, Mini-Mental score examination (MMSE) and olfaction test 1 day before (baseline) and 1 week,3 months,1 year and 3 years after surgery without safety issue.We also measure their preoperative leukocyte telomere length.
control group	Neuropsychology test	We enroll 50 healthy volunteers and do the neuropsychological tests, Mini-Mental score examination (MMSE) and olfaction test at 1 day (baseline), 1 week, 3 months, 1 year and 3 years without safety issue.

Primary Outcome Measures

Name	Time	Method
the neuropsychological test to measure cognitive function	within the first 3 years (plus or minus 1 year) after surgery
Mini-Mental score examination [MMSE] used for screening of dementia	within the first 3 years (plus or minus 1 year) after surgery
the leukocyte telomere length	on the surgery day

Trial Locations

Locations (1)

Department of Anesthesia of the Affiliated Hospital of Xuzhou Medical University; 🇨🇳 Xuzhou, Jiangsu, China