NCT03703973UnknownNot Applicable
Correlation Between Postoperative Cognitive Dysfunction and Telomere Length in Patients With Non-cardiac Surgery
Xuzhou Medical University1 site in 1 country1,000 target enrollmentStarted: August 1, 2016Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Enrollment
- 1,000
- Locations
- 1
- Primary Endpoint
- the neuropsychological test to measure cognitive function
Study Overview
Brief Summary
To study on the Postoperative Cognitive Dysfunction: Correlations With Leukocyte telomere length。
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 60 Years to 85 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Non-cardiac surgery patients;
- •Age is greater than or equal to 65 years old;
- •Han Nationality, mother tongue is chinese;
- •④The MMSE score:Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points;
- •⑤The Geriatric Depression Scale (GDS) grade 1 or 2;
- •⑥The important function without serious heart, brain, liver, kidney, lung and other organs;
- •The ASA class I or II;
- •The people signed informed consent.
Exclusion Criteria
- •The diagnosis of neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's syndrome, multiple sclerosis, schizophrenia, depression, etc.; ②Had severe head and face disease, trauma history or history of surgery;
- •Had a history of influenza in 3 weeks; ④The serious body disease and tobacco, wine and other substance abuse history; ⑤The presence of malignant tumor with shorter survival disease.
Outcomes
Primary Outcomes
the neuropsychological test to measure cognitive function
Time Frame: within the first 3 years (plus or minus 1 year) after surgery
Mini-Mental score examination [MMSE] used for screening of dementia
Time Frame: within the first 3 years (plus or minus 1 year) after surgery
the leukocyte telomere length
Time Frame: on the surgery day
Secondary Outcomes
No secondary outcomes reported
Investigators
Han Yuan
Doctor-in-charge of Anesthetist
Xuzhou Medical University
Study Sites (1)
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