Relative oral bioavailability of GABA from tomatoes
- Conditions
- n.a. healthy research subjects
- Registration Number
- NL-OMON25547
- Lead Sponsor
- Wageningen University and Research
- Brief Summary
n.a.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 12
BMI between 18.5 and 25 kg/m2
-Age is between 18 and 28 years
-Good general health
-Male
-Veins suitable for blood sampling
-Able to speak Dutch
-Is currently suffering from a disease including mental disorders
-Has had any gastrointestinal condition/disease within the 3 months prior to
the intervention
-Haemoglobin (Hb) level < 8.5 mmol/L
-Has used medication in the two months before and/or during the intervention.
- Occasional use of NSAIDs or paracetamol ( allowed.
-Reported weight loss or weight gain of > 2 kg in the month prior to the
intervention
-Use of dietary supplements, 3 weeks before-, or during the intervention.
-Allergic to products that are provided as part of the standardised diet
-Unwilling to consume the products that are part of the standardised diet
-Allergic to tomatoes
-(History of) drug abuse, in this case meaning >1 x per month use of
recreational drugs
-Smoking
-Alcohol consumption of >10 standardised glasses per week.
-Not able to refrain from alcohol consumption 2 days before each test day
-Recent or planned blood donation (<3 month prior to first study day or during
intervention)
-Personnel of Wageningen University, department of Human Nutrition and
Health,
-Currently participating in other research or was participating in another study
within 1 month of the intervention or within 3 months if invasive procedures
were used.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The main study parameter is the plasma-time curve of GABA after intake of a GABA supplement and tomatoes. This will be studied using descriptive kinetics (maximum peak height (Cmax), time-to-peak (Tmax), Half-life (T1/2) and area-under-the-curve (AUC)).
- Secondary Outcome Measures
Name Time Method Secondary study parameters are:<br>-The plasma-time curves of glutamate in response to a glutamate supplement <br> and tomatoes. <br>-The plasma-time curves of GABA in response to a glutamate supplement in <br> comparison to the plasma time-curves of GABA after tomato intake. <br>