Magnesium Sulfate Combined With Intraarticular Cocktail Injection for Analgesia After Simultaneous Bilateral Total Knee Arthroplasty
- Registration Number
- NCT06445829
- Lead Sponsor
- Chang Gung Memorial Hospital
- Brief Summary
Total knee arthroplasty is a safe procedure with excellent outcome. In recent years, simultaneous bilateral total knee arthroplasty has become more popular. In views of enhanced recovery after surgery, intraarticular cocktail injection for pain control has been developed. However, the safety accumulation dose for simultaneous bilateral knee injection is still an issue. Recently, adding magnesium sulfate to intraarticular cocktail injection in unilateral total knee arthroplasty has been proved effective for prolong pain control. We tempt to conduct a double blinded study to evaluate that whether adding magnesium sulfate intraarticular cocktail injection to one of the knees in simultaneous bilateral total knee arthroplasty patient could effectively decrease pain score with less analgesia dose or not.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 80
- bilateral knee advanced osteoarthritis or osteonecrosis who tend to receive simultaneous bilateral total knee arthroplasty
- hypersensitivity to magnesium sulfate
- hypermagnesemia
- severe cardiac, hepatic or renal compromised
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Cocktail injection with Magnesium Sulfate Magnesium sulfate Cocktail injection with Marcaine, Dexamethasone, normal saline and Magnesium Sulfate
- Primary Outcome Measures
Name Time Method VAS score day 0, day 1, day 2, day 3, day 7 muscle power day 0, day 1, day 2, day 3 Straight leg raised test day 0, day 1, day 2, day 3 active range of motion day 0, day 1, day 2, day 3
- Secondary Outcome Measures
Name Time Method Magnesium level in blood day 0, day 1 Calcium level in blood day 0, day 1