NCT04802668已完成不适用
Factors Influencing the Reliability of Pulse Pressure Variation (PPV) as a Predictor of Fluid Responsiveness in Mechanically Ventilated Patients
Southeast University, China1 个研究点 分布在 1 个国家目标入组 189 人开始时间: 2021年3月20日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 189
- 试验地点
- 1
- 主要终点
- cardiac output(CO)
研究概览
简要总结
The investigators studied the predictive value of PPV in the patients with different influencing factors;and the method to improve the predictive value,which can improve the application of PPV in ICU.
详细描述
PPV can be used to predict fluid responsiveness in patients with circulatory shock.However, it is affected by many factors, which leads to the decrease of the applicability of PPV in ICU.Therefore, the investigators studied the predictive value of PPV in the patients with different influencing factors;and the method to improve the predictive value,which can improve the application of PPV in ICU.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients requiring invasive mechanical ventilation
- •Acute circulatory failure,defined as:systolic blood pressure <90 mmHg or blood pressure in patients with previous hypertension lower than the baseline value> 40 mmHg; vasoactive drugs are required to maintain blood pressure (mean arterial pressure> 65 mmHg); with or without signs of hypoperfusion (oliguria<0.5ml.kg-1.h-1 for at least 2 hours; arterial blood lactic acid>2.5mmol.L-1; skin mottling)
排除标准
- •The age of the patient is less than 18 years old or more than 80 years old
- •Refuse to sign the informed consent to join the group
- •Atrial fibrillation and other arrhythmias that seriously affect the output per beat;
- •With pregnancy
- •Other situations where the clinician believes that the patient is not suitable for inclusion in the study
结局指标
主要结局
cardiac output(CO)
时间窗: 1 day
The measurement of cardiac output(CO);
次要结局
- measurement of Hemodynamic variables from the monitor;(1 day)
- measurement of airway pressure variables from ventilator(1 day)
- Pocc(1 day)
- measurement of Pulse pressure variation（PPV）from monitor;(Research period)
- P 0.1(1 day)
研究者
Ling Liu
Clinical Professor
Southeast University, China
研究点 (1)
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