A Comparative Study Between the Effect of Addition of MgSO4 or Dexamethasone to Bupivacaine on the Prolongation of Ultrasound-guided Quadratus Lumboram Block
Overview
- Phase
- Not Applicable
- Intervention
- Bupivacaine- Magnesium
- Conditions
- Post Operative Pain
- Sponsor
- Ain Shams University
- Enrollment
- 66
- Locations
- 1
- Primary Endpoint
- Duration of post-operative analgesia
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The goal of postoperative pain management is the provision of comfort, early mobilization and improved respiratory function without causing inadequate sedation and respiratory compromise, which can be achieved through using regional anethesia.
This study aimed to assess the analgesic effect of adding dexamethasone or magnesium sulphate with bupivacaine in ultrasound-guided QLB to prolong its duration in patients undergoing open abdominal surgeries in the early postoperative period regarding pain relief After approval of the ethical committees in Ain Shams University Hospitals, patients undergoing open abdominal surgeries were included in the study, and were divided into three groups (n=22; each); group M, D and group C. In Group A, patients (n=22) received 20 ml bupivacaine 0.25% plus 5 ml of 10% MgSO. In group B, patients (n=22) received 20 ml bupivacaine 0.25% plus 8 mg dexamethasone (2 ml) plus 3 ml 0.9% NaCl. In group C (control), patients (n=22) received 20 ml bupivacaine plus 5 ml 0.9% NaCl.
Investigators
Ghada M.Samir
Assistant Professor
Ain Shams University
Eligibility Criteria
Inclusion Criteria
- •American Society of Anesthesiologists (ASA) physical status I or II
- •aged 18 to 65 years
- •body weight ≥ 60 kg and ≤ 90 kg
- •scheduled for open abdominal surgeries
Exclusion Criteria
- •Patients' refusal to participate in the study
- •history of allergy to the medications used in the study
- •hepatic disease
- •renal disease
- •known neurologic disorders
- •psychiatric disorder
- •chronic treatment with calcium channel blockers
- •hyper-magnesemia
- •coagulopathy
- •anatomical abnormalities
Arms & Interventions
Bupivacaine Magnesium sulphate group
Patients received QL block with 20 ml of 0.25% bupivacaine (2, 4)plus 5 ml of 10% MgSO4.
Intervention: Bupivacaine- Magnesium
Bupivacaine Dexamethasone group
Patients received QL block with 20 ml of 0.25% bupivacaine (2,4)plus 2 ml of 8 mg dexamethasone plus 3 ml of 0.9% NS.
Intervention: Bupivacaine dexamethasone
bupivacaine saline group
Patients received QL block with 20 ml of 0.25% bupivacaine (2,4)plus 5 ml of 0.9% NS.
Intervention: Bupivacaine saline
Outcomes
Primary Outcomes
Duration of post-operative analgesia
Time Frame: 24hours
Time from completion of the block to the first request of rescue analgesia.
Secondary Outcomes
- Mean arterial blood pressure(24 hours)
- Heart rate(24 hours)
- The severity of post-operative pain at rest(24 hours)
- The severity of post-operative pain with movement (bilateral knee flexion)(24 hours)
- Number of patients requiring post-operative rescue analgesia(24 hours)
- Total dose of pethidine given(24 hours)
- Occurrence of nausea and/or vomiting:(24 hours)
- Time to first ambulation(24 hours)
- The analgesic satisfaction at 24 post-operative hours(24 hours)
- Inadvertent femoral nerve block(24 hours)
- Local Anesthetic Systemic Toxicity (LAST):(24 hours)