Magnesium Sulphate and Extubation Quality

Phase 4

Completed

• Conditions: Perioperative Complication
• Interventions: Drug: Saline; Drug: Magnesium sulfate

• Registration Number: NCT05858957
• Lead Sponsor: Cukurova University

Brief Summary

The investigators aimed to search effect of magnesium Sulfate on extubation quality scores, recovery and pain in larynx micro surgery. The patients allocated to two groups to receive magnesium sulfate 30 mg/kg in 100 ml saline infusion (maximum 2g) (Group m) or saline 100 ml (Group S) before induction of anesthesia. Anesthesia induction performed with propofol 2 mg/kg, rocuronium 0.6 mg/kg, remifentanil 0.5 µg/kg and general anesthesia maintained with total intravenous anesthesia (propofol 3-7 mg/kg, remifentanil 0.05-0.1 µg/kg/min and O2/air 30/70 mixture) to the all patients. Extubation quality scores, Extubation time, NRS scores were assessed.

Detailed Description

The investigators aimed to search effect of magnesium sulfate on extubation quality, recovery feature and complications.98 adult patients scheduled for larynx laser microsurgery were included and randomly allocated to two groups to receive magnesium sulfate 30 mg/kg in 100 ml saline infusion (maximum 2g) (Group m) or saline 100 ml (Group S) before induction of anesthesia. Anesthesia induction performed with propofol 2 mg/kg, rocuronium 0.6 mg/kg, remifentanil 0.5 µg/kg and general anesthesia maintained with total intravenous anesthesia (propofol 3-7 mg/kg, remifentanil 0.05-0.1 µg/kg/min and O2/air 30/70 mixture) to the all patients. Paracetamol 15 mg/kg applied to all patients.Extubation quality score, extubation time, stay in postanesthesia unit (PACU) time, numeric rating scale (NRS) and complications were recorded.

Study Timeline

• Status Verified: 2023-04
• Study First Submitted: 2023-04-18
• Study Start: 2023-04-20
• Study First Submitted QC: 2023-05-11
• Study First Posted: 2023-05-15
• Primary Completion: 2023-07-15
• Study Completion: 2023-07-30
• Last Update Submitted: 2024-01-16
• Last Update Posted: 2024-01-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 98

Inclusion Criteria

• 18 age over
• American society of Anesthesiology (ASA) clinical status I-III
• the patients who experience larynx micro surgery

Exclusion Criteria

• under 18 years old
• ASA IV and over
• severe airway obstruction
• neuromuscular disease
• presence of tracheostomy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Saline	Saline	saline 100 ml will apply in 10 min before induction of general anesthesia (Group S) . When the saline infusion completed, general anesthesia induction will start.
Magnesium	Magnesium sulfate	Magnesium sulfate 30 mg/kg with 100 ml saline will apply in 10 min before induction of general anesthesia (maximum magnesium dose 2g) (Group M) . When the magnesium infusion completed, general anesthesia induction will start.

Primary Outcome Measures

Name	Time	Method
extubation quality scores	at the time between stop the total intravenous anesthesia and extubation of patient (last 20 min of anesthesia).	Extubation quality will assess with quality scores such as no cough, Mild cough, moderate cough, severe cough.

Secondary Outcome Measures

Name	Time	Method
extubation time	time between stop the total intravenous anesthesia and extubation of patient (last 20 min of anesthesia).	The time need to adequate spontaneous ventilation at recovery period

Trial Locations

Locations (1)

Cukurova University; 🇹🇷 Adana, Turkey