Diaphragmatic ultrasonographic evaluation as an assessment guide for predicting noninvasive ventilation failure in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Completed

• Conditions: Acute exacerbation of chronic obstructive pulmonary disease; diaphragmatic excursion, diaphragmatic thickness fraction, ultrasound, respiratory failure, noninvasive ventilation

• Registration Number: TCTR20240527004
• Lead Sponsor: /A

Brief Summary

Diaphragmatic ultrasound, especially DTF, is a validated tool for predicting NIV failure in patients with AECOPD. Early detection of diaphragmatic dysfunction with diaphragmatic ultrasound in AECOPD with NIV could help identify high-risk patients and guide clinical decisions

Detailed Description

Not available

Study Timeline

• Study Completion: 2022-09-30
• Study Start: 2024-05-27
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 113

Inclusion Criteria

Patients who were diagnosed with AECOPD and who were indicated for the use of NIV according to the GOLD recommendations for at least one of the following criteria were enrolled: respiratory acidosis (partial pressure of arterial carbon dioxide (PaCO2) >45 mmHg and blood pH <7.35), severe dyspnea with clinical signs of increased of breathing, and persistent hypoxemia despite supplemental oxygen therapy including high flow nasal cannula and bronchodilator therapy

Exclusion Criteria

Individuals with pulmonary edema, thoracic deformity, a history of neuromuscular diseases, indications for intubation at the beginning, who were transferred to other hospitals before intubation, who did not undergo intubation, or who did not consent to participate.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
IV failure 48 hours requiring intubation

Secondary Outcome Measures

Name	Time	Method
IV duration day of discontinue NIV discontinue NIV