Behavioral and Neurobiological Changes over the Course of theMenstrual Cycle in Women with Alcohol Use Disorder - Cycle-AUD

Zentralinstitut für Seelische Gesundheit (ZI)0 个研究点目标入组 72 人开始时间: 2023年12月20日最近更新: 2024年8月19日

适应症

试验速览

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•Female sex at birth
•- Regular menstrual cycle with a duration between 21 and 35 days in the last three months
•- Body mass index 18.5-30.0 kg/m²
•- AUD according to DSM-5 (American Psychiatric Association, 2013)
•- Ability to give informed written consent and to undergo functional magnetic resonance imaging
•- Written Informed Consent available
•- Sufficient knowledge of the German language
•- Breath alcohol concentration of 0.0 per mille

•- Medical history of bipolar disorder, psychotic disorder, schizophrenia or schizophrenic spectrum disorder, or substance use disorder other than alcohol, nicotine, or cannabis, treated as an outpatient or inpatient
•- History of severe head injury or other severe central nervous system disease (e.g., dementia, Parkinson's disease, multiple sclerosis)
•- Intake of drugs or medications that interact with the central nervous system within the last 10 days or if their use was less than 5 half-lives in the past
•- Intake of contraceptives or other hormones that affect the menstrual cycle
•- Breastfeeding
•- Active wish to become pregnant
•- Exclusion criteria for an MRI examination
•- Known intolerance to high-frequency flickering visual stimuli
•- Presence of premenstrual dysphoric disorder according to SIPS

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