NCT03017703已完成不适用
The Role of Aldosterone in Diabetes Related Vascular Disease, a New Therapeutic Target?
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 27
- 试验地点
- 1
- 主要终点
- Insulin sensitivity measured by a insulin clamp
研究概览
简要总结
The importance of Aldosterone for endothelial function and Insulin resistance observed within patients with type 2 diabetes
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosed diabetic < 5 Yrs.
- •BMI < 32 kg/m2
- •Non-smoking
- •Blood pressure < 140/90 mmHg (treatment with maximum of two antihypertensive drugs)
排除标准
- •Insulin treatment
- •Hypertension (>140/90 mmHg)
- •Sequelae to diabetes
- •Known chronic diseases
- •Pregnancy or birth within 3 month
- •Alcohol misuse
研究组 & 干预措施
Type 2 Diabetes
Experimental
8 weeks of treatment with Aldosterone blocker Eplerenone
干预措施: Eplerenone (Drug)
Healthy
Experimental
8 weeks of treatment with Aldosterone blocker Eplerenone
干预措施: Eplerenone (Drug)
结局指标
主要结局
Insulin sensitivity measured by a insulin clamp
时间窗: 8 weeks
Glucose infusion rate during euglycaemic-hyperinsulinaemic clamp
Vascular function
时间窗: 8 weeks
Femoral arterial blood flow in response to femoral arterially infused ACh
次要结局
- Vascular function(8 weeks)
研究者
Stefan Mortensen
Associate Professor
University of Southern Denmark
研究点 (1)
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