Nitroglycerine Versus Dexmedetomidine Infusion in Intraoperative Management of Uncontrolled Hypertension

Completed

• Conditions: Hypertension
• Interventions: Drug: Dexmedetomidine; Drug: Nitroglycerin

• Registration Number: NCT04953156
• Lead Sponsor: National Cancer Institute, Egypt

Brief Summary

This study aim to compare the efficacy of intraoperative dexmedetomidine infusion versus Nitroglycerin infusion in cancer patients with accidental uncontrolled intraoperative elevation of blood pressure.

Detailed Description

Nitroglycerine is a direct vessel wall vasodilator with more venodilator effect than arterial dilator effect. It is used as an anti-anginal and antihypertensive drug. On the other hand, dexmedetomidine is a highly selective alpha 2 adrenergic agonist with sympatholytic effect. This study aim to compare the efficacy of intraoperative dexmedetomidine infusion versus Nitroglycerin infusion in cancer patients with accidental uncontrolled intraoperative elevation of blood pressure.

Study Timeline

• Study First Submitted: 2021-06-28
• Study First Submitted QC: 2021-06-28
• Study Start: 2021-07-03
• Study First Posted: 2021-07-07
• Primary Completion: 2022-11-20
• Study Completion: 2022-12-10
• Status Verified: 2023-01
• Last Update Submitted: 2023-01-08
• Last Update Posted: 2023-01-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 77

Inclusion Criteria

• Cancer patients with controlled hypertension and undergoing surgical procedures under general anesthesia
• ≥ Age 18 years.

Exclusion Criteria

• patient refusal
• patients on Beta blockers
• kidney or liver function impairment
• bradycardia, any degree of heart block and severe cardiorespiratory disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Dexmedetomidine	Dexmedetomidine	patients will receive dexmedetomidine bolus dose of 1 mic/kg over 20 minutes followed by intravenous infusion of 0.2-0.7 mic/kg/hr adjusted according to each patient hemodynamic response
Nitroglycerin	Nitroglycerin	data of patients meeting the eligibility criteria and received nitroglycerine infusion will be retrieved from medical records.

Primary Outcome Measures

Name	Time	Method
Intraoperative blood pressure values	Intraoperative period	measurements of blood pressure

Secondary Outcome Measures

Name	Time	Method
Intraoperative heart rate values	operative time	measurements of intraoperative heart rate

Trial Locations

Locations (1)

National Cancer Institute; 🇪🇬 Cairo, Egypt