Comparison of two drugs named dexmedetomidine and ketamine during general anesthesia (state of unconsciousnessor asleep) in brain surgeries for maintenance of blood pressure, heart rate, depth of sleep and pain control during surgery and post surgery pain management intervention.
Not Applicable
- Conditions
- Health Condition 1: - Health Condition 2: C719- Malignant neoplasm of brain, unspecified
- Registration Number
- CTRI/2022/10/046643
- Lead Sponsor
- Paras Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1 Patients aged 18 - 65 years. 2 American Society of Anesthesiologists I/II. 3 Elective supratentorial craniotomy
Exclusion Criteria
1 Known allergy to drugs.
2 History of renal,liver, cerebrovascular and cardiovascular (mod/severe) disease.
3 Chronic beta blocker treatment with heart rate or preoperative HR < 50/min.
4 Isolated frontal lobe surgery.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Hemodynamic parameters - Mean arterial pressure( MAP)Timepoint: Baseline values will be recorded (average of 3) prior to start of study drug. At 0,5 and 10 mins hemodynamic parameters and BIS are recorded. Then at induction , intubation and incision. In between recordings at 15 min interval. At stopping study drug and starting atracurium. Followed by stopping atracurium and tapering propofol. Again recordings will be taken at emergence and extubation
- Secondary Outcome Measures
Name Time Method Hemodynamic parameter SBP and DBP, HR, BIS <br/ ><br>Requirement of other annaetshetic drugs propofol, atracurium. <br/ ><br>Vas score post extubation <br/ ><br>Analgesic requirement. <br/ ><br>Timepoint: Baseline values will be recorded (average of 3) prior to start of study drug. At 0,5 and 10 mins hemodynamic parameters and BIS are recorded. Then at induction , intubation and incision. In between recordings at 15 min interval. At stopping study drug and starting atracurium. Followed by stopping atracurium and tapering propofol. Again recordings will be taken at emergence and extubation <br/ ><br>Visual analogue scale till 24 hours post surgery.