The effect of letrozole and N-acetylcysteine in the treatment of infertility in patients with polycystic ovary syndrome

Phase 2

Recruiting

Conditions: Polycystic ovary syndrome.
Polycystic ovarian syndrome
E28.2

Registration Number: IRCT20221019056244N1

Lead Sponsor: Tabriz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Female

Target Recruitment: 20

Inclusion Criteria

Ovulation disorder (oligo ovulation or anovulation).
Clinical or laboratory evidence of high testosterone levels
Morphology of polycystic ovary in ultrasound
Normal thyroid function
Normal prolactin test
At least one year has passed since the patient's infertility.
Normal analysis of the patient’s husband’s semen

Exclusion Criteria

Thyroid dysfunction.
Uterine abnormalities leading to infertility
Ovarian cysts larger than 6 centimeters.
History of asthma.
Taking any drug effective in glucose metabolism
Abnormality of prolactin tests

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hyaluronan synthase 2 gene expression level. Timepoint: About 14 days after the start of the treatment, we will not measure at the beginning of the study. Method of measurement: Polymerase chain reaction device.;Versican gene expression level. Timepoint: About 14 days after the start of the treatment, we will not measure at the beginning of the study. Method of measurement: Polymerase chain reaction device.

Secondary Outcome Measures

Name	Time	Method
Phosphofructokinase, Platelet gene expression level. Timepoint: About 14 days after the start of the treatment, we will not measure at the beginning of the study. Method of measurement: Polymerase chain reaction device.;Pyruvate kinase M2 gene expression level. Timepoint: About 14 days after the start of the treatment, we will not measure at the beginning of the study. Method of measurement: Polymerase chain reaction device.