NCT03850548已完成不适用
Chronic Infections on Articular Prostheses With C. Acnes Diagnosed by Specific PCR : Descriptive Study of 6 Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 6
- 试验地点
- 1
- 主要终点
- Rate of diagnostic delay
研究概览
简要总结
Osteaoarticular infection due to C. acnes are known to be of late onset, causing chronic infection possibly pauci-symptomatic. Osteaoarticular infection due to C. acnes represents a diagnostic challenge, since C. acnes is slow and difficult to grow, and can also be considered a contaminant.A 16S universal PCR bacteriological diagnosis has been proposed but is lacking of sensitivity. A specific C. acnes PCR was developed in 2010, but is not used routinely.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients having had infection prothesis vith C. acnes identified by PCR
排除标准
- 未提供
结局指标
主要结局
Rate of diagnostic delay
时间窗: Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption
time between surgery and detection of C. acnes by PCR
次要结局
- rate of radiologic signs(Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption)
- rate of duration of antibiotherapy(Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption)
- rate of use of this diagnostic(Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption)
研究者
Eugénie MABRUT
clinical research assistant
Hospices Civils de Lyon
研究点 (1)
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