Chronic Infections on Articular Prostheses With C. Acnes Diagnosed by Specific PCR

Completed

• Conditions: Bone and Joint Infection
• Interventions: Other: Prosthetic joint infection with Cutibacterium acnes

• Registration Number: NCT03850548
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Osteaoarticular infection due to C. acnes are known to be of late onset, causing chronic infection possibly pauci-symptomatic. Osteaoarticular infection due to C. acnes represents a diagnostic challenge, since C. acnes is slow and difficult to grow, and can also be considered a contaminant.A 16S universal PCR bacteriological diagnosis has been proposed but is lacking of sensitivity. A specific C. acnes PCR was developed in 2010, but is not used routinely.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-01-01
• Primary Completion: 2017-03-01
• Study Completion: 2018-02-01
• Status Verified: 2019-02
• Study First Submitted: 2019-02-20
• Study First Submitted QC: 2019-02-20
• Last Update Submitted: 2019-02-20
• Study First Posted: 2019-02-22
• Last Update Posted: 2019-02-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 6

Inclusion Criteria

• patients having had infection prothesis vith C. acnes identified by PCR

Read More

Exclusion Criteria

• none

Read More

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Prosthetic joint infection with Cutibacterium acnes	Prosthetic joint infection with Cutibacterium acnes	Chronic infections on articular prostheses with Cutibacterium acnes diagnosed by specific PCR

Primary Outcome Measures

Name	Time	Method
Rate of diagnostic delay	Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption	time between surgery and detection of C. acnes by PCR

Secondary Outcome Measures

Name	Time	Method
rate of radiologic signs	Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption	prosthesis loosening or not
rate of duration of antibiotherapy	Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption	measures of duration of the antibiotherapy
rate of use of this diagnostic	Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption	descriptions of patients managed with this diagnostic

Trial Locations

Locations (1)

Hospices Civils de Lyon; 🇫🇷 Lyon, France