Evaluation of Endoplasmic Reticulum Stress in Patients With Recurrent Pregnancy Loss

Completed

• Conditions: Recurrent Pregnancy Loss; Endoplasmic Reticulum Stress
• Interventions: Other: x box binding protein

• Registration Number: NCT04455256
• Lead Sponsor: Kanuni Sultan Suleyman Training and Research Hospital

Brief Summary

To evaluate endoplasmic reticulum stress in women with recurrent pregnancy loss and those who had healthy births in the same age group. The level of the unfolded protein X box binding protein 1 (XBP-1) is measured. It is aimed to show the effect of endoplasmic reticulum stress on recurrent pregnancy loss.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-03-20
• Study First Submitted: 2020-06-28
• Study First Submitted QC: 2020-06-28
• Status Verified: 2020-07
• Primary Completion: 2020-07-01
• Study First Posted: 2020-07-02
• Study Completion: 2020-07-07
• Last Update Submitted: 2020-07-15
• Last Update Posted: 2020-07-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 90

Inclusion Criteria

• with three or more miscarriages before 20 th week of gestation
• had no chronic or acute inflammatory disease
• used no steroids, anti-inflammatory, or antioxidant medications

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Exclusion Criteria

• had inflammatory diseases
• had systemic disease
• Anatomical abnormalities, infectious, endocrine, or genetic etiologies

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
women who had healthy birth	x box binding protein	Women between the ages of 18-45 who have not had a history of pregnancy loss and who have had at least one healthy birth and no known chronic diseases are included in this group.
recurrent pregnancy loss group	x box binding protein	Women between the ages of 18 and 45 who had a history of miscarriage under 3 weeks and above 22 weeks were included in this group.

Primary Outcome Measures

Name	Time	Method
Show the effect of endoplasmic reticulum stress on recurrent pregnancy loss	3 months	Serum value (pg / mL) of x box binding protein (XBP-1), which is one of the unfolded proteins indicating endoplasmic reticulum stress, is measured.

Trial Locations

Locations (1)

Pinar Yalcin Bahat; 🇹🇷 Istanbul, İ̇stanbul, Turkey