Retinal Ganglion Cell Layer in Patients With Intracerebral Processes

Completed

• Conditions: Ganglion Cells

• Registration Number: NCT02407886
• Lead Sponsor: University of Zurich

Brief Summary

Transsynaptic degeneration of the retinogeniculate pathways is well documented to occur in nonhuman primates when the cerebral lesion occurs even during adulthood. In case of humans, retrograde transsynaptic degeneration of the retinogeniculate pathways has been shown to occur following prenatal or perinatal lesions, but its occurrence after cerebral lesions in adults is considerable rare. It is, however, well established that retrograde transsynaptic degeneration affects other neural systems in humans even when the injury occurs during adulthood. Some histopathological evidence points to the possibility of transsynaptic degeneration of the retinogeniculate pathway in humans even when the lesion occurs in adults, but the clinical significance is unknown.'

Purpose:

To measure the retinal ganglion cell layer (GCL) in patients with visual field defects due to intracerebral processes. To correlate GCL with the localization and type of intracerebral lesion.

To compare the GCL with the retinal nerve fibre layer (RNFL) to investigate, which of the 2 parameters is more sensitive to show retinal layer abnormalities.

To correlate GCL with visual field defects and electrophysiological parameters.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-03
• Study First Submitted: 2015-03-05
• Study First Submitted QC: 2015-03-30
• Study First Posted: 2015-04-03
• Primary Completion: 2015-12
• Study Completion: 2016-05
• Status Verified: 2017-05
• Last Update Submitted: 2017-05-24
• Last Update Posted: 2017-05-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• adult patients with intracerebral lesions within the central visual tract
• associated visual field defects
• investigations (OCT, ERG) possible

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Exclusion Criteria

• lesions within the optic nerve without extension in the optic tract
• neurological disease
• optic disc anomalies: glaucoma, nystagmus, high myopia

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ganglion cell thickness	measurements will be taken at a minimum of 4 weeks after the inital diagnosis

Trial Locations

Locations (1)

University Hospital Zurich; 🇨🇭 Zurich, Switzerland