Metabolic health and immune status in young obese subjects

• Conditions: E66; E11; Type 2 diabetes mellitus; Obesity

• Registration Number: DRKS00015784
• Lead Sponsor: ehrstuhl für Epidemiologie, Universität Augsburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-11-23
• Results First Posted: 2023-06-03
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 238

Inclusion Criteria

Age: 25-65 years
Exposure: Normal weight (BMI: 20-24.99 kg/m²) and overweight/adipose (BMI: >30kg/m²)

Exclusion Criteria

- Antibiotics or corticosteroids use 3 months prior to the baseline visit
- Current use of immunosuppressive medicine
- History of significant illness
- Acute febrile illness

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
B-lymphocytes (FACS)

Secondary Outcome Measures

Name	Time	Method
Oral glucose tolerance test. <br>Immunophenotyping of T-cell subpopulations (CD4+, CD8+, NK cells, Tregs, memory T cells),<br>Inflammation markers: Plasma levels of interleukins, IFN-gamma, CCL5, TNF-alpha