Role of serum biomarkers predicting neurological outcome in Birth asphyxia
Not Applicable
- Conditions
- Health Condition 1: null- Collecting venous blood sample and assessing serum biomarkers assay for correlating with neurological outcome and multiorgan dysfunction.
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
Neonates born at >=36 weeks of gestation and > 1800 gm birth weight with perinatal asphyxia are eligible. Perinatal asphyxia in patients born at the study
hospital or any other health facility was defined as the need for resuscitation at birth, along with the presence of one or more of the following.
1.Apgar score of <6 at 5 min after
birth,
2.Continued need for resuscitation, for > 5 mins
3.umbilical cord pH or any arterial pH of <7.00 within
60 min of birth and base deficit of >16 mmol/L within
60 min of birth
Exclusion Criteria
1.Babies with Major congenital anomalies
2.Babies arriving after 24 hours of age completed
3. Babies enrolled in Therapeutic Cooling Study
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To study correlation between s protein 100B,CARDIAC TROPONIN,CYSTATIN C,LDH with neurological outcome at 14 days and 90 days of ageTimepoint: 0,1,3,14,90 days
- Secondary Outcome Measures
Name Time Method To compare serum biomarkers against NICHD score in predicting neurological outcome. <br/ ><br> <br/ ><br>6. Study of correlation between MODS and neurological outcome at 14 days/later and 3months of age <br/ ><br> <br/ ><br>7. Neurological outcome at discharge by Hammersmith examination <br/ ><br> <br/ ><br>8. To compare above serum biomarkers against Mortality rate <br/ ><br>Timepoint: 0,1,3,14,90 days