Correlation Between Markers of Neuronal Injury and Cognitive Dysfunction After Coronary Artery Bypass Surgery

• Conditions: Postoperative Cognitive Dysfunction

• Registration Number: NCT01550159
• Lead Sponsor: Maria José Carvalho Carmona

Brief Summary

This study aims to evaluate the possible Correlation Between Serum Levels of Markers of Neuronal Injury and Cognitive Dysfunction after Coronary Artery Bypass Surgery.

Detailed Description

The systemic inflammatory response after cardiac surgery may cause damage to the central nervous system and elevated markers of brain injury in peripheral blood. This event may be potentially related to the development of postoperative cognitive dysfunction (POCD), with incidences varying from 20 to 83%.

Study Timeline

• Study Start: 2009-04
• Study First Submitted: 2012-02-06
• Status Verified: 2012-03
• Study First Submitted QC: 2012-03-06
• Last Update Submitted: 2012-03-06
• Study First Posted: 2012-03-09
• Last Update Posted: 2012-03-09
• Primary Completion: 2013-02
• Study Completion: 2013-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 88

Inclusion Criteria

• Patients underwent for coronary artery bypass graft surgery

Exclusion Criteria

• History of brain disease or dementia, other psychiatric disorders that affect cognition
• Lack of proficiency in Portuguese language

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Score in Neuropsycological Tests	1 year	Tests for evaluation of quality of life, depressive synths and neuropsycho;logical battery to assess general mental status, learning, attention, visuospatial perception, immediate memory, operational and executive ask and recall, including processing speed. This assessment will be applied before surgery, and 3, 7,21 90 and 180 days after surgery.

Trial Locations

Locations (1)

General Hospital of the University od São Paulo Medical School; 🇧🇷 São Paulo, Brazil