NCT00637442Unknown不适用
Continuous Arterial Spin Labeling (CASL) MRI for Monitoring and Prediction of Drug Therapy in Alzheimers Disease (AD)
University Hospital, Bonn1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2008年2月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Cerebral perfusion
研究概览
简要总结
Examination of the correlation between the cerebral bloodflow and the clinical change under treatment with Reminyl retard® and the prediction of clinical change by measuring the cerebral bloodflow in patients with mild to moderate Alzheimer's Disease
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Possible Alzheimer's Disease according to ICD-10 and NINCDS-ADRDA
- •Underwritten study consent
- •No treatment with acetylcholinesterase inhibitors
- •Mini-Mental-State Examination: 12-25 points
- •Age: 50-80 Years
- •Orale contraception for women of child-bearing age
排除标准
- •Mental Disorders
- •Other Diseases of the CNS
- •Severe Illness
- •Contraindication for MRI-Scan
- •Contraindication for Galantamin (Reminyl retard®)
- •Participation at other clinical trials
研究组 & 干预措施
CASL-MRI
Experimental
Drug monitoring with CASL-MRI for new diagnosed patients with mild to moderate Alzheimer's Disease treated with Reminyl
干预措施: Reminyl retard (Drug)
结局指标
主要结局
Cerebral perfusion
时间窗: baseline and after 12 weeks
次要结局
- Change of Alzheimer Disease Assessment Scale, cognitive part (ADAScog)(baseline, after 12 and 24 weeks)
- Alzheimer's Disease Functional Assessment and Change Scale (ADFACS)(baseline, after 12 and 24 weeks)
- Neuropsychiatric Inventory (NPI)(baseline, after 12 and 24 weeks)
- Mini-Mental-Status-Examination (MMSE)(baseline, after 12 and 24 weeks)
研究者
研究点 (1)
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