Effect of Menstrual Cycle on Traumatic Systemic Response
- Conditions
- Systemic Inflammatory Response Syndrome
- Interventions
- Procedure: modified radical mastectomy
- Registration Number
- NCT03283345
- Lead Sponsor
- Kocaeli University
- Brief Summary
It is aimed to evaluate pathophysiology of systemic responses to trauma via using interleukin (IL) -1 and IL-6 levels and determining timing of surgery through phases of menstrual cycle.
- Detailed Description
89 female breast cancer patient who underwent modified radical mastectomy included into study. Menstrual history and hormone levels were used to determine menstrual phase: luteal, follicular, and other. IL-1β and IL-6 levels, which are related to severeness of inflammation, were measured one day before and one day after surgery. Those are statistically analysed to show effect of timing of breast surgery on responses to trauma in postmenopausal and premenopausal women during different phases of their menstrual cycles
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 89
- female patients
- who underwent modified radical mastectomy for breast cancer
- who signed informed consent forms
- For premenopausal patients taking oral contraceptives
- for postmenopausal patients taking hormone replacement therapy.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description postmenopausal women modified radical mastectomy postmenopausal female breast cancer patients who underwent modified radical mastectomy premenopausal women modified radical mastectomy premenopausal female breast cancer patients who underwent modified radical mastectomy
- Primary Outcome Measures
Name Time Method IL-1 and IL-6 levels 5 month evaluate pathophysiology of systemic responses to trauma via using IL-1 and IL-6 levels.
- Secondary Outcome Measures
Name Time Method