Exploring the multi-dimensional regulatory mechanism of acupuncture on the

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: Not specified

Inclusion Criteria

(1) Those who meet the diagnostic criteria for CSU/chronic addiction rash in EAACI/GA2LEN/EDF/WAO Guidelines for Definition, Classification, Diagnosis and Treatment of Urticaria and Traditional Chinese Medicine Diagnosis and Efficacy Criteria for Diseases and Syndrome;
(2) Right-handed; 18 years old = age = 70 years old, education = 6 years, both male and female;
(3) 7-day urticaria activity score (Urticaria Activity Score 7, UAS7)>14;
(4) There are no metal implants in the body, and there is no contraindication to fMRI scanning;
(5) No antihistamines within 2 weeks before entering the study, no steroid hormones and immunosuppressive drugs within 1 month;
(6) Those who did not receive acupuncture and moxibustion treatment or participated in other ongoing clinical investigators 3 months before entering the study;
(7) Sign the informed consent form and voluntarily participate in this researcher.
Note: Only patients who meet the above 7 items can be included in this study.

Exclusion Criteria

(1) Those with claustrophobia and other contraindications to MRI;
(2) Journalists who cannot understand or record the urticaria day;
(3) Pregnant women and lactating women;
(4) Patients with serious primary diseases such as cardiovascular, liver, kidney, digestive and hematopoietic systems;
(5) Progressive malignant tumor or other serious wasting diseases, who are prone to infection and bleeding;
(6) Those who are unconscious, unable to express subjective discomfort symptoms or mentally ill;
(7) Participated in similar researchers within 1 month.
Note: All patients who meet any one of the above items will be excluded.

Study & Design

Study Type: Interventional study

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
rticaria Activity Score 7,UAS7;

Secondary Outcome Measures

Name	Time	Method
Dermatology Life Quality Index,DLQI;Pruritus Visual Analogue Scale,VAS-P;Hamilton Depression Scale,HAMD;skin flora;Pittsburgh Sleep Quality Index,PSQI;skin reactions (diameter, height, temperature, humidity, etc.);Intestinal flora;Brain functional MRI (resting state, dynamic functional connectivity; analysis of microstate extraction techniques);Blood sample index (blood routine, liver and kidney function, total IgE, cytokines, etc.);Hamilton Anxiety Scale,HAMA;Demographics, vital signs and condition data;