Creatine Monohydrate Supplementation in Young, Healthy Vegetarian Adults and Its Effect on Brown Adipose Tissue Activation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Brown adipose tissue activation through 18F-FDG PET-MRI
研究概览
简要总结
Pre-clinical studies indicate that creatine may play a substantial role in diet-induced thermogenesis and may have a profound effect on energy balance. A recent retrospective study of BAT activation on PET-CT scans in humans showed a positive association with the estimated renal creatinine clearance and BAT activation, possibly linking creatine metabolism in humans to BAT activity. In humans, so far little options are available to activate brown adipose tissue. The most potent intervention to activate BAT is via cold, which has previously been shown to have metabolic effects in humans. Provided the potential health benefits of brown adipose tissue activation in humans, and provided the role of brown fat in diet induced thermogenesis, we here aim to determine whether creatine monohydrate supplementation can increase diet-induced thermogenesis and activate brown adipose tissue in humans.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female;
- •18 to 30 years of age;
- •Consuming a vegetarian diet;
- •BMI 20-25 kg/m2.
排除标准
- •Not meeting all inclusion criteria;
- •Non-vegetarian diet;
- •Excessive alcohol and/or drug abuse;
- •Significant allergies or intolerances concerning the study products;
- •Participation in another biomedical study within 1 month before the first study visit, possibly interfering with the study results;
- •Medication use known to hamper subject's safety during the study procedures;
- •Subjects with contra-indications for MRI and/or PET-CT;
- •Subjects who do not want to be informed about unexpected medical findings;
- •Subjects who do not want that their treating physician to be informed;
- •Co-morbidities to which the intervention or program that may pose as a complicating factor;
- •Inability to participate and/or complete the required measurements;
- •PET-CT scan in the last 12 months.
结局指标
主要结局
Brown adipose tissue activation through 18F-FDG PET-MRI
时间窗: Day 10 of protocol
Standard Uptake Value (SUV)
次要结局
- Posphocreatine (PCr) Recovery through 31P-MRS(Day 9 of protocol)
- Diet-induced thermogenesis through indirect calorimetry(Day 8 of protocol)
研究者
Patrick Schrauwen
Principal Investigator
Maastricht University