Creatine Effect on Brown Adipose Tissue Activation

Not Applicable

Completed

• Conditions: Brown Adipose Tissue Activation; Diet-induced Thermogenesis
• Interventions: Dietary Supplement: Creatine monohydrate; Dietary Supplement: placebo cellulose

• Registration Number: NCT04086381
• Lead Sponsor: Maastricht University

Brief Summary

Pre-clinical studies indicate that creatine may play a substantial role in diet-induced thermogenesis and may have a profound effect on energy balance. A recent retrospective study of BAT activation on PET-CT scans in humans showed a positive association with the estimated renal creatinine clearance and BAT activation, possibly linking creatine metabolism in humans to BAT activity. In humans, so far little options are available to activate brown adipose tissue. The most potent intervention to activate BAT is via cold, which has previously been shown to have metabolic effects in humans. Provided the potential health benefits of brown adipose tissue activation in humans, and provided the role of brown fat in diet induced thermogenesis, we here aim to determine whether creatine monohydrate supplementation can increase diet-induced thermogenesis and activate brown adipose tissue in humans.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-05-01
• Study First Submitted: 2019-09-10
• Study First Submitted QC: 2019-09-10
• Study First Posted: 2019-09-11
• Primary Completion: 2020-01-22
• Study Completion: 2020-01-22
• Status Verified: 2021-02
• Last Update Submitted: 2021-02-22
• Last Update Posted: 2021-02-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• Male or female;
• 18 to 30 years of age;
• Consuming a vegetarian diet;
• BMI 20-25 kg/m2.

Exclusion Criteria

• Not meeting all inclusion criteria;
• Non-vegetarian diet;
• Excessive alcohol and/or drug abuse;
• Significant allergies or intolerances concerning the study products;
• Participation in another biomedical study within 1 month before the first study visit, possibly interfering with the study results;
• Medication use known to hamper subject's safety during the study procedures;
• Subjects with contra-indications for MRI and/or PET-CT;
• Subjects who do not want to be informed about unexpected medical findings;
• Subjects who do not want that their treating physician to be informed;
• Co-morbidities to which the intervention or program that may pose as a complicating factor;
• Inability to participate and/or complete the required measurements;
• PET-CT scan in the last 12 months.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Intervention	Creatine monohydrate	Oral injestion of 20 grams of creatine monohydrate daily
Placebo	placebo cellulose	Oral injestion of 20 grams of cellulose daily

Primary Outcome Measures

Name	Time	Method
Brown adipose tissue activation through 18F-FDG PET-MRI	Day 10 of protocol	Standard Uptake Value (SUV)

Secondary Outcome Measures

Name	Time	Method
Posphocreatine (PCr) Recovery through 31P-MRS	Day 9 of protocol	Halftime of PCr Recovery
Diet-induced thermogenesis through indirect calorimetry	Day 8 of protocol	Whole body energy expenditure in kJ/kg/min

Trial Locations

Locations (1)

Maastricht University; 🇳🇱 Maastricht, Limburg, Netherlands