Functional Characteristic Properties of Skeletal Muscle Tissue Assessed by P31 Spectroscopy in Young and Older Adults

Not Applicable

Terminated

• Conditions: Sarcopenia
• Interventions: Radiation: SRM P31

• Registration Number: NCT03336294
• Lead Sponsor: University Hospital, Toulouse

Brief Summary

P31 nuclear magnetic resonance (RMN) Spectroscopy (SRM P31) has currently being poorly used in the field of sarcopenia.

The aim of the CAMUS study is to investigate the feasibility a protocol of SRM P31 at rest, during and after a standardized physical task. The secondary objective is to compare the metabolism of tyhe skeletal muscle tissue assessed by SRM P31 in young and older individuals. A pilot study, cross-sectional study will be conducted. Ten healthy sedentary 70+ years males and 10 sedentary 25 to 30 years old male will be included.

Level of physical activity, physical performances, will be assessed at baseline. RMN (T1; tractography and SRM P31) will be performed. SRM P31 will be performed at rest, during and after an exhausting muscle task at 70% 1-RM. Feasibility will be judged on the rate of valuable variables recorded (\>90%) inorganic phosphate (iP), phosphocreatine (PCr) and isoform of adenosine triphosphate (ATP : alfa, beta, gamma).

Detailed Description

Not available

Study Timeline

• Study Start: 2013-04-01
• Study First Submitted: 2014-01-07
• Study First Submitted QC: 2017-11-05
• Study First Posted: 2017-11-08
• Primary Completion: 2017-12-31
• Study Completion: 2017-12-31
• Status Verified: 2019-07
• Last Update Submitted: 2019-07-15
• Last Update Posted: 2019-07-16

Recruitment & Eligibility

• Status: TERMINATED
• Sex: Male
• Target Recruitment: 1

Inclusion Criteria

• Old group : 70+ years males
• Young group : 25 to 30 years males
• Sedentary males in the 2 groups
• Informed consent

Exclusion Criteria

• Contraindication to perform a RMN

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Old group	SRM P31	Subjects involved in the CAMUS study will perform during the SRM P31 a quadricipital physical task at 70% 1-RM.
Young group	SRM P31	Subjects involved in the CAMUS study will perform during the SRM P31 a quadricipital physical task at 70% 1-RM.

Primary Outcome Measures

Name	Time	Method
SRM P31 assessment	Change of SRM P31 between during and after a standardized physical task	Feasibility of a protocol of SRM P31 at rest, during and after a standardized physical task defined by a composite criteria : the rate of valuable variables recorded (\>90%) inorganic phosphate (iP), phosphocreatine (PCr) and isoform of ATP (alfa, beta, gamma) on the spectre.

Secondary Outcome Measures

Name	Time	Method
T1; tractography and SRM P31 comparison between young and older sedentary adults	Change between during and after a standardized physical task	To compare the RMN (T1; tractography and SRM P31) at rest, during and after an exhausting muscle task at 70% 1-RM between young and older sedentary adults.

Trial Locations

Locations (1)

University Hospital Toulouse; 🇫🇷 Toulouse, France