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Clinical Trials/NCT03677999
NCT03677999
Withdrawn
Not Applicable

Spectroscopic Magnetic Resonance Imaging of Glioma

University of Minnesota1 site in 1 country304 target enrollmentJune 1, 2019

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Brain Tumor-Glioma
Sponsor
University of Minnesota
Enrollment
304
Locations
1
Primary Endpoint
The number of brain cancer participants with IDH mutation status
Status
Withdrawn
Last Updated
last year

Overview

Brief Summary

The study is designed to develop and test new Magnetic Resonance Imaging methods that can improve the characterization of brain cancer and facilitate improved clinical care of these participants.

Detailed Description

The primary objective of this study is to develop and test new Magnetic Resonance Imaging methods that can improve the characterization of brain cancer and facilitate improved clinical care of these participants. More specifically, investigators are interested in applying novel spectroscopic and quantitative MR methods that give information beyond what is produced by a clinical brain MRI study and to understand the clinical correlates of the imaging findings. Investigators have tested these sequences in healthy volunteers. The investigators now wish to test these sequences in brain cancer participants in order to understand how these sequences can best be applied in a clinical setting. To acquire these data, investigators intend to perform additional MRI acquisitions on participants who are scheduled to receive a clinical MRI at the UMN Center for Clinical Imaging Research (CCIR), a facility located at the Center for Magnetic Resonance Research (CMRR). Since these MRIs are required for the participants' clinical care, the participant will not be making additional visits to the CCIR. Based on published data and pilot experiences reported from other institutions, the sequences are well-tolerated. The only imposition for the participant is that the participant will spend additional time in the scanner after completion of the imaging required for clinical care. An informed consent form describing the additional MR sequences performed will be presented to the participant.

Registry
clinicaltrials.gov
Start Date
June 1, 2019
End Date
September 14, 2025
Last Updated
last year
Study Type
Observational
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Men and women scheduled who are diagnosed with glioma who is seeking clinical care for their conditions at the UMN Masonic cancer center.
  • Passed the safety screen for MRI
  • Age 18 or older
  • Ability to read and understand English
  • Ability to provide informed consent

Exclusion Criteria

  • Participants who are excluded from the base MRI scan, as determined by the CMRR/CCIR clinical policies are necessarily excluded from this study, as the MRI scan will not be performed.
  • Pregnant women

Outcomes

Primary Outcomes

The number of brain cancer participants with IDH mutation status

Time Frame: 30 minutes

MEGA-PRESS MRI sequence will be utilized to determine IDH status

Study Sites (1)

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