Polymorphids an mRNA Expression in Obese Genes

Completed

• Conditions: mRNA Expression; Polymorphism

• Registration Number: NCT01708083
• Lead Sponsor: Karolinska Institutet

Brief Summary

Fat tissue from omenta, thigh and abdomen taken under anesthesia on subjects undergoing laparoscopic surgery, cholecystectomy, reflux surgery or gastric by-pass (GBP).

Are there any difference in polymorphids and/or mRNA expression in genes significant for developing obesity, between normal weight and obese individuals, with or without diabetes typ 2 .

Are there any difference in polymorphids and/or mRNA expression in different types of fat tissue

Detailed Description

Not available

Study Timeline

• Study Start: 2010-01
• Study First Submitted: 2012-10-09
• Study First Submitted QC: 2012-10-15
• Study First Posted: 2012-10-16
• Primary Completion: 2013-02
• Study Completion: 2013-02
• Status Verified: 2013-08
• Last Update Submitted: 2013-08-21
• Last Update Posted: 2013-08-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• age 18 years or older
• laparoscopic surgery (Gastric by-pass, cholecystectomy, antireflux surgery)
• Normal weight without type 2 diabetes BMI 18-25
• Obese without type 2 diabetes BMI>35
• Obese with type 2 diabetes BMI>35

Exclusion Criteria

• under 18 years
• open surgery
• pregnancy
• BMI >27-<35

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Differences in polymorphids and/or mRNA expression in genes, significant for developing obesity and type 2 diabetes, between patients with normal weight and obesity	approximatly 30 minutes after start of operation	fat biopsy taken from abdomen, omenta and thigh at surgery
Difference in polymorphids and/or mRNA expression in different types of fat tissue in patients with normal weight or obesity with or without diabetes type 2	approximatly 30 minutes after start of operation	fat biopsy; abdomen, omenta and thigh taken at surgery

Trial Locations

Locations (2)

Karolinska Institutet, CMM; 🇸🇪 Stockholm, Sweden

Ersta hospital; 🇸🇪 Stockholm, Stockholm County Council, Sweden