Stimulation of the autonomic nervous system in colorectal surgery by perioperative nutritio

Completed

• Conditions: lekkage van de darmaansluiting; verlamming van de darm; 10017990; 10017998

• Registration Number: NL-OMON41286
• Lead Sponsor: Catharina-ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 280

Inclusion Criteria

- patients that undergo colorectal surgery with primary anastomosis
- written informed consent
- age above 18 years

Exclusion Criteria

- use of medication that disrupts acetylcholine metabolism
- steroid use
- previous gastric or esophageal resection
- peritoneal metastases found during surgery
- pre-existent or creation of an ileostomy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main clinical outcome parameter is postoperative ileus. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Anastomotic leakage<br /><br>- Aspiration pneumonia<br /><br>- Gastric volumes preoperatively<br /><br>- Length of functional recovery<br /><br>- The local and systemic inflammatory response<br /><br>- Surgical complications<br /><br>- Length of stay<br /><br>- Intestinal barrier function and local inflammation in the gut<br /><br>- Need for additional surgical, radiological or endoscopic interventions<br /><br>- Need for ICU admission and total length of ICU stay<br /><br>- micriobiota in feces pre and postoperatively<br /><br>- Quality of life (EQ-5D and EORTC-QLQ-C30 at baseline, after 3 and 6 months)</p><br>