The influence of apical periodontitis on the concentration of inflammatory mediators in peripheral blood plasma and the metagenomic profiling of endodontic infections.
Completed
- Conditions
- apical periodontitis, parodontitis apicalisoral inflammation, ontsteking in de mondroot canal infection, wortelkanaalinfectieendodontic, endodontischhealth, gezondheidsystemic health, algehele gezondheidlow-grade inflammation, lage-graad ontsteking
- Registration Number
- NL-OMON23636
- Lead Sponsor
- Academic Centre Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
Inclusion criteria AP group
In order to be eligible to participate in this study, a subject must meet all of the following criteria.
Exclusion Criteria
A potential subject who meets any of the following criteria will be excluded from participation in this study:
-smoking
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in concentration of mediators of inflammation compared non-AP controls (i) and to baseline measurements (ii).<br /><br>Determination of the magnitude of the microbial infection.<br /><br>Determination of composition and function profile of infected AP teeth.
- Secondary Outcome Measures
Name Time Method Presentation of cytokine timelines of resolution of AP plus healing of extraction site.<br><br /><br /><br>Determination of clusters of inflammatory mediators at time points S1- S6.<br /><br /><br><br>Correlation of subject characteristics (symptoms of AP, DMFS and DPSI, age and sex) to mediators of inflammation or clusters thereof. <br><br /><br /><br>Correlation of subject characteristics (symptoms of AP, DMFS and DPSI, age and sex) to qualitative and quantitative data of microbial content of extracted teeth.