Exercise Training in Patients With Pulmonary Arterial Hypertension

Not Applicable

Completed

• Conditions: Pulmonary Arterial Hypertension

• Registration Number: NCT05242380
• Lead Sponsor: Saglik Bilimleri Universitesi

Brief Summary

In this study, the effects of kettlebell exercise training on functional capacity, dyspnea and activities of daily living in patients diagnosed with Pulmonary Arterial Hypertension (PAH) will be investigated.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-12-25
• Study First Submitted QC: 2022-02-06
• Study First Posted: 2022-02-16
• Study Start: 2022-06-10
• Primary Completion: 2023-09-15
• Study Completion: 2023-09-15
• Status Verified: 2023-10
• Last Update Submitted: 2023-10-26
• Last Update Posted: 2023-10-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

• Patients diagnosed with pulmonary arterial hypertension (PAH) by a specialist physician in accordance with the 2015 guideline for the treatment and diagnosis of pulmonary hypertension of the European Heart and Respiratory Societies (ERS/ESC),
• Patients with stable pharmacological treatment,
• Patients clinically stable at least last three months.

Exclusion Criteria

• Presence of orthopedic or neurological problems that will affect functional tests and muscle strength measurement,
• Recent surgical procedures,
• Recent syncope,
• Pregnancy,
• Presence of severe left heart failure,
• Presence of severe ischemic heart disease,
• Hypertensive patients,
• Patients who have problems in communicating.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Task related oxygen uptake	8 weeks	Cardiopulmonary data will be evaluated with mobile cardiopulmonary exercise test during daily activities. Participants will perform the following activities with mobile cardiopulmonary exercise test (CPET): putting on socks on both feet (sitting on a chair), putting on both shoes (sitting on a chair), putting on a coat (while standing), lifting material (placing 6 jars -each 400 gram- at chest-level height), sweeping the floor for 4 minutes, washing dishes for 4 minutes, go up and down stairs - 1 floor. There will be a 5 minute rest between all activities.
Peripheral muscle strength	8 weeks	Isometric muscle strength will be measured with a handheld dynamometer for elbow flexion, knee extension, knee flexion, shoulder flexion, shoulder abduction, hip flexion and m.serratus anterior.
Handgrip strength	8 weeks	Hand grip strength will be measured with a digital hand dynamometer.
Functional capacity	8 weeks	The 6-minute walk test will be performed.

Secondary Outcome Measures

Name	Time	Method
Activity status	8 weeks	This outcome will be assessed with the Duke Activity Status Index. As a result of scoring, a total score ranging from 0 to 58.2 is obtained. Higher scores indicate higher functional capacity.
Health-related quality of life	8 weeks	This outcome will be assessed with the emPHasis-10. emPHasis-10 consists of 10 items and results in a score out of 50, where a higher score represents a higher symptom burden.
Activities of daily living	8 weeks	This outcome will be assessed with the London Chest Activity of Daily Living Scale. It is a questionnaire consisting of fifteen items. Each item is given a score ranging from 0 to 5. Higher scores indicate greater limitation in activities of daily living. The total score can reach a maximum of 75
Sleep quality	8 weeks	This outcome will be assessed with the Pittsburgh Sleep Quality Index. The questionnaire consists of 19 individual items. Each item is given a score ranging from 0 to 3, providing an overall score ranging from 0 to 21, where lower scores denote a healthier sleep quality.

Trial Locations

Locations (1)

Istanbul University - Cerrahpasa, Institute of Cardiology; 🇹🇷 Istanbul, Turkey