Coagulation Factors Alterations in Patients Undergoing Complex Thoraco-abdominal Aortic Aneurysm Repair
- Conditions
- Platelet ActivationThoraco-abdominal Aortic Aneurysm RepairCoagulation Factors Alterations
- Registration Number
- NCT06432387
- Lead Sponsor
- University of Thessaly
- Brief Summary
This study will evaluate the impact of complex thoraco-abdominal aortic aneurysm repair in coagulation during the immediate postoperative period in patients undergoing omplex thoraco-abdominal aortic aneurysm repair.
- Detailed Description
Endovascular aneurysm repair of abdominal aorta activates a significant inflammation reaction and has an impact on coagulation. Platelet activation seems to have a major role in this prothrombotic and hypercoagulable state. In complex thoraco-abdominal aortic aneurysm repair the implants are more complexed and the duration of operation longer. The main hypothesis is that all the above have a greater impact on platelet activation and coagulation alterations.
The aim of this study is the evaluation of the impact of complex thoraco-abdominal aortic aneurysm repair in coagulation during the immediate postoperative period in patients undergoing omplex thoraco-abdominal aortic aneurysm repair.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 58
- Consecutive patients undergoing complex thoraco-abdominal aortic aneurysm repair in University Hospital of Larissa, after informed consent will be included.
- Refuse to participate
- Prior surgery within 3 months
- ASA PS > 3
- Known medical history of thrombophilia or functional platelet dysfunction
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Acute kidney injury Day of surgery, 1st postoperative day, 4-5th postoperative day Early preoperatively, early and late postoperatively
Post-implantation syndrome Day of surgery, 1st postoperative day, 4-5th postoperative day Early preoperatively, early and late postoperatively
Major cardiovascular events Day of surgery, 1st postoperative day, 4-5th postoperative day Early preoperatively, early and late postoperatively
Major cardiovascular events, implant failure and death of any cause 30 days, 3, 6, and 12 months postoperatively Early preoperatively, early and late postoperatively and 1 at one month
Coagulation status Day of surgery, 1st postoperative day, 4-5th postoperative day Early preoperatively, early and late postoperatively
Myocardial injury after non cardiac surgery Day of surgery, 1st postoperative day, 4-5th postoperative day Early preoperatively, early and late postoperatively
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Thessaly
🇬🇷Larissa, Greece
University of Thessaly🇬🇷Larissa, Greece