Muscle Strength, Muscle Endurance, Flexibility and Balance in Young Healthy Adults After COVID-19 Infection
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 118
- 试验地点
- 2
- 主要终点
- Quadriceps femoris strength
研究概览
简要总结
Purpose:
The aim of this study is to evaluate muscle strength, muscle endurance, flexibility, and balance in individuals after mild COVID-19 infection and compare them with healthy individuals.
Methods:
A total of 118 individuals, 59 individuals between the ages of 18-30 who had COVID-19 (not vaccinated) and 59 individuals who did not, will be included in the study. Lower and upper extremity muscle strength, flexibility, and static and dynamic balances of the individuals will be evaluated and compared with the control group. The descriptive characteristics of the individuals will be recorded. The physical activity level of the individuals will be determined by the Short Form of International Physical Activity Questionnaire. The strength of knee extension and elbow flexion will be evaluated with a dynamometer, and functional trunk strength will be evaluated with sit-ups and push-ups tests. Lateral bridge test, modified Biering-Sorensen test, trunk flexors endurance test, and prone bridge test will be used to evaluate muscle endurance. Participants will perform sit and reach test and back scratch test for flexibility. The one-leg stance test and the functional reach test will be used to evaluate static and dynamic balance. The level of fatigue experienced by individuals during walking and running will score according to the Modified Borg Scale.
Results:
The SPSS for Windows 19.0 (IBM SPSS Statistics for Windows, Armonk, NY: IBM Corp.) will be used for data analysis. The data will be expressed as mean standard deviation (x±SD) and percentage (n%). The homogeneity of the groups will be evaluated with the Levene Test. Between groups, muscle strength, flexibility, and balance values will be compared using the "Mann Whitney-U" Test. The statistical significance level will be accepted as a p <0.05 value.
Conclusion:
The researchers will discuss the results in light of the recent literature.
详细描述
Introduction Pandemic is the general name given to epidemic diseases that spread and affect more than one country in the world. Most recently Coronavirus Disease 2019 (COVID-19) had a place among the epidemic diseases (Pollard, 2020). Although COVID-19 is involved in the primary respiratory system as acute respiratory distress syndrome, it also affects the cardiovascular and neurological systems (Guan,2020). The most common symptoms of COVID-19 infection are fever, cough, dyspnea, muscle pain, and fatigue. Infection can be seen in all age groups, especially in the elderly. The symptoms and course of the disease differ in children, young and older adults.
COVID-19 infection can be categorized clinically as mild, moderate, or severe (critical illness). The disease affects 80% of individuals with a mild/moderate clinical condition. Patients with mild symptoms and no pneumonia are in this group. Severe illness is seen with symptoms such as dyspnea, hypoxia, and affects more than 50% of the lungs in 24-48 hours. Approximately 14% of patients are in this group. Critical illness is seen at a rate of 2%. Patients should be followed in the intensive care unit because of a severe clinical picture such as respiratory failure, shock, and multi-organ failure (Mizumoto,2020).
Due to its effects on the pulmonary, cardiovascular and neurological systems, COVID-19 causes the physical functions of individuals to be adversely affected (Lau, 2005; Fiani, 2020). In the peripheral nervous system involvement, there are symptoms such as musculoskeletal pain, paresthesia, ataxia, and muscle weakness. In central nervous system involvement, there are findings such as headache and vertigo (Stevens, 2007).
When all these symptoms that occur with COVID-19 infection are combined with the negative effects of isolation and inactivity, it has been observed that physical fitness decreases in individuals (Pinho,2020).
In the literature, various studies evaluated physical fitness in middle-aged and elderly individuals who have had COVID-19 (Pinho,2020; Rooney 2020). These studies show that aerobic endurance and functional capacity of individuals decreased after COVID-19 infection (Rooney,2020). Some studies reported there is a decrease in muscle strength (Lee,2020; Carfi,2020).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Inclusion criteria for individuals diagnosed with COVID-19 (Pinho,2020):
- •Individuals between the ages of 20-30
- •Individuals who were diagnosed with COVID-19 positive in the last 3-10 months and were treated with home isolation and whose last PCR test was negative
- •Individuals who had not to get vaccinated
- •Individuals whose physical activity level is between 600-3000 MET min/week according to "International Physical Activity Questionnaire-Short form (IPAQ-SF)" (sedentary)
- •Inclusion criteria of healthy individuals (Control group):
- •Individuals between the ages of 20-30
- •Individuals who have not been diagnosed with COVID-19 positive
- •Individuals who had not to get vaccinated
- •Individuals whose physical activity level is between 600-3000 MET min/week according to the IPAQ-SF (sedentary)
排除标准
- •Individuals who are hospitalized and treated for COVID-19
- •Individuals with previously diagnosed Chronic Obstructive Pulmonary Disease (COPD), heart disease, and/or rheumatic diseases
- •Individuals who have had surgery in the last six months
结局指标
主要结局
Quadriceps femoris strength
时间窗: Once time, 3 minutes
To measure the knee extension strength, the individual brings the knee from 90 degrees flexion to full extension in sitting. To standardize the test, the lower extremities will be fixed of the chair with a belt, allowing full extension of the knee. Three measurements will be performed from the distal tibia with a dynamometer, and the score will be recorded in Newtons.
Lower extremity flexibility-Sit and reach test
时间窗: Once time, 2 minutes
Sit and reach test evaluates lower extremity flexibility. In the test, a sit and reach board with 30 cm height, 45 cm width, and 100 cm length is used. The "0" reference point is taken as the 25 cm inner part where the feet are placed on the sit and reach the board. The part closer to the individual from the reference point shows negative values, and the part towards the far side shows positive values. Individuals will reach as far as with their fingertips by placing their feet on a sit-and-reach board. The test is repeated three times. The average score is recorded
Functional strength of trunk muscles-Sit-ups test
时间窗: Once time, 2 minutes
The sit-ups test is a measure the endurance of the abdominal and hip-flexor muscles. The physiotherapist will fix the feet and ask the individuals to do trunk flexion in the knee flexion position. The number of movements performed for 30 seconds will be recorded.
Biceps brachii strength
时间窗: Once time, 3 minutes
Elbow flexion will also be measured in a sitting position in a chair. To standardize the given resistance, the upper extremity of the individual will be fixed to the arm support of the chair, allowing elbow flexion with a belt. During the measurement, the individual will try to flex the forearm in supination. Meanwhile, three measurements will be taken from the distal forearm with a dynamometer. The average score will be recorded in Newtons.
Functional strength of trunk muscles-Push-ups test
时间窗: Once time, 2 minutes
The test will be in the prone position, with the hands at shoulder level and the elbows flexed, positioned near to the body. Individuals will raise the head, shoulders, and trunk from the ground with their elbows in full extension. The test is performed with the knees in full extension for men and modified knees in flexion for women. The number of movements performed for 30 seconds will be recorded.
Muscle Endurance-Trunk flexors endurance test
时间窗: Once time, 5 minutes
Trunk flexion test involving a static, isometric contraction of the anterior muscles, stabilizing the spine until the individual exhibits fatigue. The researcher stops the test when the individual cannot hold the assumed position. Higher scores indicate a good level of endurance.
Dynamic balance
时间窗: Once time, 5 minutes
Functional reach test The functional reach test evaluates dynamic balance and limit of stability. This test measures the distance between the length of an outstretched arm in a maximal forward reach from standing while maintaining a fixed base of support. The scoring record is centimeter. Higher scores indicate a good level of balance
Upper extremity flexibility-Back scratch test
时间窗: Once time, 3 minutes
The back-scratch test evaluates upper extremity flexibility. The individual will externally rotate one arm over her/his shoulder to reach the lowest point on the back with the palm facing the back. The other extremity reaches the highest point on the back with the palm facing forward by internal rotation of the other arm. The distance between the middle fingers of both hands will be measured with a tape measure. If the middle fingers do not touch each other, the distance between them is recorded as a minus value in centimeters, if fingers can reach completely, as a zero value, if the fingers cross each other, as a positive value in centimeters
Muscle Endurance-Lateral bridge test
时间窗: Once time, 5 minutes
Lateral bridge test involves static, isometric contractions of the lateral muscles on each side of the trunk that stabilizes the spine. Higher scores indicate a good level of endurance.
Muscle Endurance- Biering-Sorensen test
时间窗: Once time, 5 minutes
The test measuring how many seconds the individual can keep the unsupported upper body (from the upper border of the iliac crest) horizontal, while placed prone with the buttocks and legs fixed to the couch by three wide canvas straps and the arms folded across the chest. Higher scores indicate a good level of endurance.
Muscle Endurance- Prone bridge test
时间窗: Once time, 5 minutes
The prone bridge test measures the muscular endurance of the abdominal muscles. Higher scores indicate a good level of endurance.
Static balance
时间窗: Once time, 5 minutes
Single leg stance test Individuals bend one knee and place the sole on the other thigh and maintain their balance in this position. The test will be performed separately for the right and left extremities with eyes open and closed. The single-leg stance balance time was recorded as seconds.
次要结局
- Fatigue-modified Borg scale(Once time, 2 minutes)
研究者
Ozlem Yuruk
Assoc. Prof.
Baskent University