Determination of Risk Factors, Incidence and Mortality Rates of Acute Kidney Injury in COVID-19 Patients Hospitalized in Intensive Care Unit
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 238
- 试验地点
- 1
- 主要终点
- Intensive care unit mortality
研究概览
简要总结
This retrospective observational study aims to determine the incidence of acute kidney injury (AKI) associated with COVID-19, risk factors, and effects on mortality for intensive care unit patients. Data from 238 COVID-19 patients monitored in the Anesthesiology and Reanimation Intensive Care Unit of Ankara University Ibni Sina Hospital between January 1, 2021 and January 1, 2022 were retrospectively reviewed. Patients were divided into two groups according to the level of renal damage (with and without AKI). Those with AKI were staged per the KDIGO criteria (Stage 1-2-3). Demographic data, comorbidities, Charlson comorbidity indexes, Acute Physiology and Chronic Health Evaluation scores, laboratory results, and mortality data were examined. The data obtained were compared between the groups.
The findings may help improve clinical awareness and guide management strategies in intensive care unit patients with COVID-19 at risk of AKI
详细描述
This retrospective, single-center observational study was conducted at Ankara University Hospital. Data from 238 COVID-19 patients monitored in the Anesthesiology and Reanimation Intensive Care Unit of Ankara University Ibni Sina Hospital between January 1, 2021 and January 1, 2022 were retrospectively reviewed. The objective of the study was to investigate the frequency, risk factors, and impact on mortality of acute kidney injury (AKI) in adult patients hospitalized with confirmed COVID-19 infection.
Patients with a confirmed diagnosis of COVID-19 and available renal function data were included in the analysis. AKI was defined and staged according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Demographic characteristics, comorbidities, laboratory values, and clinical parameters were evaluated to identify potential risk factors for AKI development. The relationship between the presence and severity of AKI and in-hospital mortality was assessed.
The study aims to provide insight into the burden of COVID-19-associated AKI and to support improved clinical decision-making for identifying and managing high-risk patients in hospital settings.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 years or older
- •Hospitalized patients with COVID-19 confirmed by PCR test
- •Required follow-up in the intensive care unit between January 1, 2021 and January 1, 2022
排除标准
- •Patients with end-stage renal disease (ESRD)
- •History of renal transplantation
- •Intensive care unit stay shorter than 48 hours
结局指标
主要结局
Intensive care unit mortality
时间窗: From ICU admission until in-hospital death or ICU discharge, whichever occurs first, assessed up to 90 days.
To evaluate whether the development of AKI is associated with mortality in COVID-19 patients monitored in the intensive care unit.
次要结局
- Association between patient characteristics and AKI development(From ICU admission until AKI diagnosis or ICU discharge, assessed up to 100 days.)
- Length of intensive care unit stay(From ICU admission until ICU discharge, assessed up to 12 months.)
- Incidence of acute kidney injury(From ICU admission until AKI diagnosis or ICU discharge, whichever occurs first, assessed during hospitalization (up to 100 days).)
研究者
Pınar KARABAK BİLAL
MD, Intensive Care Specialist
Ankara University