TPVB, PECSB, ESPB for Postmastectmy Pain

Not Applicable

Completed

• Conditions: Pain, Postoperative
• Interventions: Procedure: Ultrasound guided block; Drug: IV morphine

• Registration Number: NCT05076773
• Lead Sponsor: Menoufia University

Brief Summary

Aim of the work The aim of the study is to compare between the effects of ultrasound guided thoracic paravertebral block, pectoral nerve block II, and erector spinae block in management of pain during cancer breast surgeries. The hypothesis of the study is that the three groups will give comparative results.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-04-10
• Primary Completion: 2021-08-10
• Study Completion: 2021-08-10
• Status Verified: 2021-09
• Study First Submitted: 2021-09-14
• Study First Submitted QC: 2021-09-29
• Last Update Submitted: 2021-09-29
• Study First Posted: 2021-10-13
• Last Update Posted: 2021-10-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 80

Inclusion Criteria

1. ASA physical status classification class I or II
2. Age group 18 - 60 years of the female gender
3. Patients undergoing breast cancer surgeries

Exclusion Criteria

1. Patient refusal
2. History of hypersensitivity to local anesthetics
3. Bleeding disorders or patients receiving anticoagulants
4. Spine or chest wall deformities
5. Pregnancy
6. Local infection at the site of injection.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Erector spinae block Group (C)	IV morphine	Will receive erector spinae block
Paravertebral block Group (A)	IV morphine	Will receive thoracic paravertebral block
Erector spinae block Group (C)	Ultrasound guided block	Will receive erector spinae block
Paravertebral block Group (A)	Ultrasound guided block	Will receive thoracic paravertebral block
Pectoral block Group (B)	Ultrasound guided block	Will receive pectoral 1 and 2 block
Control Group (D)	IV morphine	Patient will receive opioid only for management of their perioperative pain
Pectoral block Group (B)	IV morphine	Will receive pectoral 1 and 2 block

Primary Outcome Measures

Name	Time	Method
The primary outcome of the study will be duration of analgesia (time to first rescue analgesia after administration of the block).	0-24o minutess	minutes

Secondary Outcome Measures

Name	Time	Method
Postoperative nausea and vomiting (PONV)	48 hours	4 points score of PONV (0-3) where 0=no PONV and 3=vomiting more than once
Postoperative pain	48 hours	assessed by VAS score (0-10) where 0=no pain and 10=worst pain
Total morphine consumption	48 hours	recorded postoperatively in mg

Trial Locations

Locations (1)

Faculty of Medicine Menofia University; 🇪🇬 Shibīn Al Kawm, Menofia, Egypt