SNIF study: Efficacy of nasally inhaled isopropyl alcohol for nausea in the intensive care unit: A randomised clinical trial
- Conditions
- Critical IllnessNauseaVomitingDry retchingOral and Gastrointestinal - Normal oral and gastrointestinal development and functionPublic Health - Health service research
- Registration Number
- ACTRN12623001047684
- Lead Sponsor
- Royal Adelaide Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Patients admitted to the Intensive Care Unit at the Royal Adelaide Hospital will be recruited if they meet all of the following inclusion Criteria:
1. Reports symptom of nausea or witnessed episode of vomiting / dry retching
2. Would be initiated on PONV protocol management
3. Aged 18 or above
4. Self-ventilating
Exclusion Criteria:
1. Allergy to isopropyl alcohol
2. Allergy to ondansetron
3. Inability to breathe through the nose
4. Inability to give informed consent
5. Mental or physical state precluding accurate assessment of nausea/ satisfaction scores
6. Administration of antiemetic medication within the preceding 8 hours
7. Administration of medication known to produce nausea when exposed to alcohol within the preceding 24 hours (e.g. Metronidazole, Disulfiram, Tinidazole, Trimethoprim-Sulfamethoxazole)
8. Symptoms of nausea or vomiting for > 24 hours
9. Pregnancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method