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Clinical Trials/NCT06218693
NCT06218693
Completed
N/A

VIA Family - Family Based Early Intervention Versus Treatment as Usual- 4 Year Follow-up

Mental Health Services in the Capital Region, Denmark1 site in 1 country113 target enrollmentApril 1, 2022
ConditionsMental Disorder

Overview

Phase
N/A
Intervention
Not specified
Conditions
Mental Disorder
Sponsor
Mental Health Services in the Capital Region, Denmark
Enrollment
113
Locations
1
Primary Endpoint
Change in "Strength and Difficulties Questionnaire" (SDQ)
Status
Completed
Last Updated
2 years ago

Overview

Brief Summary

This study aims to investigate the long-term effects (2.5 years after post-intervention) of a preventive family-based intervention (VIA Family) compared with treatment as usual (TAU) for children of parents with a severe mental illness.

Background:

Children of parents with a mental illness have an increased lifetime risk of developing a mental illness themselves. Preventive interventions for families with children with high familial risk can potentially disrupt the transgenerational transmission.

The current study is a follow-up study of a trial investigating the effect of the preventive intervention: the VIA Family trial.

The VIA Family trial investigated the superiority of a preventive family-based intervention, VIA Family, compared with treatment as usual (TAU) in improving children's, parents' and families' functioning and well-being. Eligible families had at least one parent with a lifetime severe mental illness diagnosis ( i.e. recurrent major or moderate depression, bipolar disorder, or schizophrenia spectrum disorder), at least one child between the ages of 6-12 years and lived within the Frederiksberg or Copenhagen (Denmark). The trial had a randomized, two-armed, parallel and controlled design. The participating families were randomly assigned to both groups with an allocation ratio of 1:1.

The current study is a follow-up study aiming to explore the effect of the intervention 2.5 years after post-intervention.

The main research questions for the current follow-up study are:

  1. Do children participating in the VIA Family intervention experience a greater decrease in symptoms of mental illness from baseline (timepoint 0) to long-term follow-up (timepoint 2) compared with children allocated to TAU?
  2. Do parents participating in the VIA Family intervention experience a greater decrease in perceived parental stress from baseline (timepoint 0) to long-term follow-up (timepoint 2) compared with parents allocated to TAU?
Registry
clinicaltrials.gov
Start Date
April 1, 2022
End Date
January 30, 2024
Last Updated
2 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Mental Health Services in the Capital Region, Denmark
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Child must have address registered in the municipality of Frederiksberg or Copenhagen.
  • At least one of the biological parents must have a diagnosis of schizophrenia spectrum disorder, bipolar affective disorder or recurrent major depression.
  • The parent with a diagnosis must have had at least one in- or outpatient contact with the mental health system within the lifetime of the child.

Exclusion Criteria

  • Parents who do not speak and understand enough Danish to be able to give informed consent for their own and for the child's participation.
  • If all family members are currently engaged in an intensive family intervention program addressing parental functioning and child development, they are excluded from the study.

Outcomes

Primary Outcomes

Change in "Strength and Difficulties Questionnaire" (SDQ)

Time Frame: Change from baseline to 4 years follow-up

Parent reported 25-items questionaire of their child's behavioural and emotional difficulties, 3-point Likert scale (0,1,2), higher scores indicate more emotional or behavioral problems

Secondary Outcomes

  • Health-Related Quality of Life Questionnaire: KIDSCREEN -10(Change from baseline to 4 years follow-up)
  • Personal and Social Performance Scale (PSP)(Change from baseline to 4 years follow-up)
  • Change in Children's Global Assessment Scale (CGAS)(Change from baseline to 4 years follow-up)
  • Change in Family Assessment Device (FAD)(Change from baseline to 4 years follow-up)
  • Change in Home Observation for Measurement of the Environment (HOME)(Change from baseline to 4 years follow-up)
  • This is Me (TIM)(Change from baseline to 4 years follow-up)
  • Parental Stress Scale (PSS)(Change from baseline to 4 years follow-up)
  • Parenting Scale (PS)(Change from baseline to 4 years follow-up)

Study Sites (1)

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