Bupivacaine Liposome Suspension Versus a Concentrated Multi Drug Periarticular Injection in 70 Patients Undergoing Total Knee Arthroplasty Without Femoral Nerve Block: a Double-blinded, Randomized Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 主要终点
- Pain Scores (Visual Analog Pain Scores)
研究概览
简要总结
Despite a robust multimodal pain management regimen, patients undergoing total knee arthroplasty (TKA) continue to report low satisfaction with postoperative pain management. Patient satisfaction further declines with any adverse event such as a drug reaction to neuroleptic medications or a patient fall due to a femoral nerve block. A new method of pain management throughout the hospital experience is warranted to improve patient satisfaction and the possibility of related adverse events. The purpose of this study is to examine if there is a difference in post operative pain and morphine (MSO4) total consumption for hospitalized TKA patients without femoral nerve block receiving an intra-operative periarticular injection of bupivacaine liposome suspension versus a concentrated multi drug.
详细描述
The void in the literature is that while multimodal pain management reduces postoperative pain in the majority of TKA patients6-14, too many are still dissatisfied with overall pain control13 and adverse drug reactions (dizziness and somnolence) to neuroleptic medications15. Additionally, postoperative falls are greater with femoral nerve blocks16, and new neurological symptoms are associated with the block17. Bupivacaine liposome suspension periarticular injection has large scale national anecdotal support for TKA pain control with avoidance of regional block adversity. There is one recent randomized control trial in TKA patients favorably comparing periarticular injection with bupivacaine liposome suspension versus bupivacaine hydrochloride (HCL)5. To date the clinical use and published evidence most robustly supports bupivacaine liposome suspension in patients undergoing bunionectomy or hemorrhoidectomy. Additionally, in preparation for shorter hospital stays for total joint arthroplasty, a more effective and better tolerated pain management solution is needed.
Hypothesis Statement:
Hospitalized TKA patients without a pre-operative femoral nerve block will experience improved postoperative pain control and less MSO4 equivalence consumption when receiving an injection of bupivacaine liposome suspension versus concentrated multi drug.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 35 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •TKA candidacy
- •Osteoarthritis
- •Failure of non-operative treatments to control knee pain
- •Patients able to understand and agree to study inclusion
排除标准
- •Subjects have orthopaedic and medical co-morbidities that would thwart postoperative pain control such as extra-articular pathology with referred pain to the knee (spinal stenosis, neuropathy,ipsilateral hip disease)
- •Severe knee deformity
- •Post-traumatic and inflammatory arthritis
- •BMI above 40
- •Patients unable to receive multimodal pain remitting agents
- •Active knee sepsis
- •Remote sites of active infection
- •Diabetes with A1C > 7
- •ASA class > lll
- •Cardiac disease failing medical clearance
- •Severe liver disease
- •PAD with AAI < 0.75
- •Seizure disorder
- •Allergic to any pain remitting agent
- •Alcohol abuse
- •Smoking abuse
研究组 & 干预措施
bupivacaine liposome suspension
bupivacaine liposome suspension periarticular injection
干预措施: bupivacaine liposome suspension (Drug)
concentrated multi drug injection
concentrated multi drug periarticular injection
干预措施: concentrated multi drug Ketorlac, Morphine PF, Epinephrine, Ropivicaine, 0.9% NaCL (Drug)
结局指标
主要结局
Pain Scores (Visual Analog Pain Scores)
时间窗: 1 day following surgery
visual analog pain scores (scale 0=no pain; 10=worst pain imaginable)
次要结局
- MS04 Equivalent Consumption(1 day following surgery)