The relationship between methotrexate drug and blood pressure in patients with rheumatoid arthritis
Not Applicable
Completed
- Conditions
- Rheumatoid ArthritisBlood pressureArterial functionInflammatory and Immune System - Rheumatoid arthritisCardiovascular - HypertensionCardiovascular - Other cardiovascular diseases
- Registration Number
- ACTRN12616001366448
- Lead Sponsor
- Flinders University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 114
Inclusion Criteria
Patients were included if:
1.Aged 18 years or older
2.Diagnosis of RA was made based on 1987 or 2010 American College of Rheumatology diagnostic criteria, and the rheumatologist diagnosis when the first date of fulfilling the diagnostic criteria was considered as RA incidence date
Exclusion Criteria
There were no exclusion criteria except if there was one of the following:
1.Sustained atrial fibrillation because arterial function cannot be examined
2.Active cancers as some anticancer drugs (including chemotherapy) induce endothelial dysfunction, which might affect the blood pressure and arterial function
3.Congestive heart failure (left ventricular diastolic dysfunction)
4.Cognitive impairment
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinic peripheral blood pressure was measured by an automatic monitor (AND automatic blood pressure monitor, model no.UA-767PC ). [Baseline, and at 8 months after the initial visit ];Ambulatory peripheral and central blood pressure were measured by the Mobil-O-Graph PWA monitor (IEM, Stolberg, Germany). Both peripheral and central blood pressure are a composite outcome. [Baseline and at 8 months after the initial visit ];Central blood pressure was measured at the clinic by the SphygmoCor (version 7.1, AtCor Medical, Sydney, Australia). [Baseline and at 8 months after the initial visit]
- Secondary Outcome Measures
Name Time Method